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Conference Paper: Postnatal development of the rat vestibulo-olivary pathway in the horizontal otolith system

TitlePostnatal development of the rat vestibulo-olivary pathway in the horizontal otolith system
Authors
KeywordsVESTIBULAR
MATURATION
FOS
LINEAR ACCELERATION
Issue Date2002
PublisherSociety for Neuroscience
Citation
Neuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 564.11 How to Cite?
AbstractTo examine the developmental profile of functionally activated otolith neurons in the vestibulo-olivary pathway, conscious Sprague-Dawley rats (P6 to adult) were subjected to sinusoidal linear acceleration along specific directions on the horizontal plane. Neuronal activation was defined by the expression of Fos protein and c-fos mRNA. Only neural areas that exhibited c-fos expression in experimental animals but not in the two control groups, viz. labyrinthectomized rats subjected to linear accelerations and normal rats that remained stationary, were analyzed. With interaural stimulation, neurons with c-fos expression were first observed in the dorsomedial cell column (DMCC), a subnucleus of the inferior olive, of P11 rats. The number of Fos-positive neurons in the DMCC increased significantly with age and reached adult level at P21. However, no labeling was evident in the DMCC of all age groups with stimulation along the antero-posterior axis. This finding indicates that DMCC neurons only receive otolith information about head movements along the interaural direction. Retrograde transport of Fluorogold identified vestibular-related areas that project to DMCC; these included medial and spinal vestibular nuclei, and prepositus hyopoglossal nucleus. Neurons in these areas showed c-fos expression with interaural stimulations at P7, i.e. 2 days earlier than those in DMCC. Our results suggest that during postnatal development, otolith neurons in the vestibulo-olivary pathway gradually achieve the capacity to code horizontal head movements. Supported by HK RGC grant
Persistent Identifierhttp://hdl.handle.net/10722/105042

 

DC FieldValueLanguage
dc.contributor.authorLi, Cen_HK
dc.contributor.authorZhang, FXen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:17:52Z-
dc.date.available2010-09-25T22:17:52Z-
dc.date.issued2002en_HK
dc.identifier.citationNeuroscience 2002, Orlando, FL, 3-7 November 2002, Presentation no. 564.11en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105042-
dc.description.abstractTo examine the developmental profile of functionally activated otolith neurons in the vestibulo-olivary pathway, conscious Sprague-Dawley rats (P6 to adult) were subjected to sinusoidal linear acceleration along specific directions on the horizontal plane. Neuronal activation was defined by the expression of Fos protein and c-fos mRNA. Only neural areas that exhibited c-fos expression in experimental animals but not in the two control groups, viz. labyrinthectomized rats subjected to linear accelerations and normal rats that remained stationary, were analyzed. With interaural stimulation, neurons with c-fos expression were first observed in the dorsomedial cell column (DMCC), a subnucleus of the inferior olive, of P11 rats. The number of Fos-positive neurons in the DMCC increased significantly with age and reached adult level at P21. However, no labeling was evident in the DMCC of all age groups with stimulation along the antero-posterior axis. This finding indicates that DMCC neurons only receive otolith information about head movements along the interaural direction. Retrograde transport of Fluorogold identified vestibular-related areas that project to DMCC; these included medial and spinal vestibular nuclei, and prepositus hyopoglossal nucleus. Neurons in these areas showed c-fos expression with interaural stimulations at P7, i.e. 2 days earlier than those in DMCC. Our results suggest that during postnatal development, otolith neurons in the vestibulo-olivary pathway gradually achieve the capacity to code horizontal head movements. Supported by HK RGC grant-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectVESTIBULAR-
dc.subjectMATURATION-
dc.subjectFOS-
dc.subjectLINEAR ACCELERATION-
dc.titlePostnatal development of the rat vestibulo-olivary pathway in the horizontal otolith systemen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLi, C: lic5@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros82115en_HK

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