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Conference Paper: Developmental expression of c-fos in canal-related brainstem neurons of rats following horizontal angular acceleration

TitleDevelopmental expression of c-fos in canal-related brainstem neurons of rats following horizontal angular acceleration
Authors
Issue Date2005
PublisherSociety for Neuroscience. The Abstracts' web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings
Citation
35th Annual Meeting of The Society for Neuroscience (Neuroscience 2005), Washington, DC, USA, 12-16 November 2005, Presentation no. 392.12 How to Cite?
AbstractTo investigate the distribution of functionally activated canal-related brainstem neurons during postnatal development, conscious Sprague-Dawley rats (P1-adult) were subjected to constant horizontal angular acceleration for 60 min. This stimulation paradigm composed of alternate modes of angular acceleration (at 150o/s2) in the clockwise (8s) and counterclockwise direction (8s), activating all hair cells of the two horizontal canals. Neuronal activation within brainstem nuclei was defined by immuno-/hybridization histochemical expression of c-fos. Labyrinthectomized controls and normal stationary controls showed only sporadic c-fos-expressing neurons. In P1-4 rats, no Fos-labeled neurons were found in the vestibular nucleus. By P5, significant Fos labeling in the medial (MV), spinal (SpV), superior (SuV) vestibular nuclei, group x and group y was identifiable. From P5-14, Fos expression increased significantly, reaching adult level at P21. In P5 rats, Fos-labeled neurons were evenly distributed throughout the entire rostrocaudal length of the MV, SpV and SuV while in adult rats Fos-labeled neurons were clustered in the caudal end of MV and SpV as well as the rostral end of SuV. In each age group, no Fos-labeling was observed in the whole lateral vestibular nucleus. In other canal-related brainstem areas such as the prepositus hypoglossal nucleus and locus coerulus, there was also an age-dependent increase in the number of Fos-labeled neurons from P5 onwards. Our findings suggest that functional connectivity between canal afferents and central vestibular neurons is established during the first postnatal week.
DescriptionSession: 392. Vestibular System: Neurophysiology of VOR and Spatial Orientation Poster
Persistent Identifierhttp://hdl.handle.net/10722/105040

 

DC FieldValueLanguage
dc.contributor.authorYiu, CNSen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorLai, CHen_HK
dc.date.accessioned2010-09-25T22:17:47Z-
dc.date.available2010-09-25T22:17:47Z-
dc.date.issued2005en_HK
dc.identifier.citation35th Annual Meeting of The Society for Neuroscience (Neuroscience 2005), Washington, DC, USA, 12-16 November 2005, Presentation no. 392.12en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105040-
dc.descriptionSession: 392. Vestibular System: Neurophysiology of VOR and Spatial Orientation Poster-
dc.description.abstractTo investigate the distribution of functionally activated canal-related brainstem neurons during postnatal development, conscious Sprague-Dawley rats (P1-adult) were subjected to constant horizontal angular acceleration for 60 min. This stimulation paradigm composed of alternate modes of angular acceleration (at 150o/s2) in the clockwise (8s) and counterclockwise direction (8s), activating all hair cells of the two horizontal canals. Neuronal activation within brainstem nuclei was defined by immuno-/hybridization histochemical expression of c-fos. Labyrinthectomized controls and normal stationary controls showed only sporadic c-fos-expressing neurons. In P1-4 rats, no Fos-labeled neurons were found in the vestibular nucleus. By P5, significant Fos labeling in the medial (MV), spinal (SpV), superior (SuV) vestibular nuclei, group x and group y was identifiable. From P5-14, Fos expression increased significantly, reaching adult level at P21. In P5 rats, Fos-labeled neurons were evenly distributed throughout the entire rostrocaudal length of the MV, SpV and SuV while in adult rats Fos-labeled neurons were clustered in the caudal end of MV and SpV as well as the rostral end of SuV. In each age group, no Fos-labeling was observed in the whole lateral vestibular nucleus. In other canal-related brainstem areas such as the prepositus hypoglossal nucleus and locus coerulus, there was also an age-dependent increase in the number of Fos-labeled neurons from P5 onwards. Our findings suggest that functional connectivity between canal afferents and central vestibular neurons is established during the first postnatal week.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience. The Abstracts' web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleDevelopmental expression of c-fos in canal-related brainstem neurons of rats following horizontal angular accelerationen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYiu, CNS: ngar650@yahoo.caen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.hkuros121802en_HK

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