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Conference Paper: Developmental expression of c-fos in canal-related brainstem neurons of rats following horizontal angular acceleration
Title | Developmental expression of c-fos in canal-related brainstem neurons of rats following horizontal angular acceleration |
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Authors | |
Issue Date | 2005 |
Publisher | Society for Neuroscience. The Abstracts' web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings |
Citation | The 35th Annual Meeting of The Society for Neuroscience (SfN) - Neuroscience 2005, Washington, DC., 12-16 November 2005, no. 392.12 How to Cite? |
Abstract | To investigate the distribution of functionally activated canal-related brainstem neurons during postnatal development, conscious Sprague-Dawley rats (P1-adult) were subjected to constant horizontal angular acceleration for 60 min. This stimulation paradigm composed of alternate modes of angular acceleration (at 150o/s2) in the clockwise (8s) and counterclockwise direction (8s), activating all hair cells of the two horizontal canals. Neuronal activation within brainstem nuclei was defined by immuno-/hybridization histochemical expression of c-fos. Labyrinthectomized controls and normal stationary controls showed only sporadic c-fos-expressing neurons. In P1-4 rats, no Fos-labeled neurons were found in the vestibular nucleus. By P5, significant Fos labeling in the medial (MV), spinal (SpV), superior (SuV) vestibular nuclei, group x and group y was identifiable. From P5-14, Fos expression increased significantly, reaching adult level at P21. In P5 rats, Fos-labeled neurons were evenly distributed throughout the entire rostrocaudal length of the MV, SpV and SuV while in adult rats Fos-labeled neurons were clustered in the caudal end of MV and SpV as well as the rostral end of SuV. In each age group, no Fos-labeling was observed in the whole lateral vestibular nucleus. In other canal-related brainstem areas such as the prepositus hypoglossal nucleus and locus coerulus, there was also an age-dependent increase in the number of Fos-labeled neurons from P5 onwards. Our findings suggest that functional connectivity between canal afferents and central vestibular neurons is established during the first postnatal week. |
Description | Session: 392. Vestibular System: Neurophysiology of VOR and Spatial Orientation Poster |
Persistent Identifier | http://hdl.handle.net/10722/105040 |
DC Field | Value | Language |
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dc.contributor.author | Yiu, CNS | en_HK |
dc.contributor.author | Chan, YS | en_HK |
dc.contributor.author | Lai, CH | en_HK |
dc.date.accessioned | 2010-09-25T22:17:47Z | - |
dc.date.available | 2010-09-25T22:17:47Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | The 35th Annual Meeting of The Society for Neuroscience (SfN) - Neuroscience 2005, Washington, DC., 12-16 November 2005, no. 392.12 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/105040 | - |
dc.description | Session: 392. Vestibular System: Neurophysiology of VOR and Spatial Orientation Poster | - |
dc.description.abstract | To investigate the distribution of functionally activated canal-related brainstem neurons during postnatal development, conscious Sprague-Dawley rats (P1-adult) were subjected to constant horizontal angular acceleration for 60 min. This stimulation paradigm composed of alternate modes of angular acceleration (at 150o/s2) in the clockwise (8s) and counterclockwise direction (8s), activating all hair cells of the two horizontal canals. Neuronal activation within brainstem nuclei was defined by immuno-/hybridization histochemical expression of c-fos. Labyrinthectomized controls and normal stationary controls showed only sporadic c-fos-expressing neurons. In P1-4 rats, no Fos-labeled neurons were found in the vestibular nucleus. By P5, significant Fos labeling in the medial (MV), spinal (SpV), superior (SuV) vestibular nuclei, group x and group y was identifiable. From P5-14, Fos expression increased significantly, reaching adult level at P21. In P5 rats, Fos-labeled neurons were evenly distributed throughout the entire rostrocaudal length of the MV, SpV and SuV while in adult rats Fos-labeled neurons were clustered in the caudal end of MV and SpV as well as the rostral end of SuV. In each age group, no Fos-labeling was observed in the whole lateral vestibular nucleus. In other canal-related brainstem areas such as the prepositus hypoglossal nucleus and locus coerulus, there was also an age-dependent increase in the number of Fos-labeled neurons from P5 onwards. Our findings suggest that functional connectivity between canal afferents and central vestibular neurons is established during the first postnatal week. | - |
dc.language | eng | en_HK |
dc.publisher | Society for Neuroscience. The Abstracts' web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings | - |
dc.relation.ispartof | Neuroscience 2005 | en_HK |
dc.title | Developmental expression of c-fos in canal-related brainstem neurons of rats following horizontal angular acceleration | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Yiu, CNS: ngar650@yahoo.ca | en_HK |
dc.identifier.email | Chan, YS: yschan@hkucc.hku.hk | en_HK |
dc.identifier.email | Lai, CH: chlaib@HKUSUA.hku.hk | en_HK |
dc.identifier.authority | Chan, YS=rp00318 | en_HK |
dc.identifier.authority | Lai, CH=rp00396 | en_HK |
dc.identifier.hkuros | 121802 | en_HK |