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Conference Paper: Expression of neurotrophin receptors in vestibular nuclei during the postnatal development of the rat

TitleExpression of neurotrophin receptors in vestibular nuclei during the postnatal development of the rat
Authors
Issue Date2001
PublisherSociety for Neuroscience
Citation
Neuroscience 2001, San Diego, CA, 10-15 November 2001. In Society for Neuroscience Abstracts, 2001, v. 27 n. 1, p. 788 Abstract no. 298.27 How to Cite?
AbstractNeurotrophins and their receptors are known to play an important role in neuronal development. Postnatal development of neurons immunoreactive for three neurotrophin receptor tyrosine kinases (TrkA, TrkB, and TrkC) was examined in the rat vestibular nuclei and subnuclei. TrkA immunoreactivity was not observed in these areas during the first two postnatal weeks, though some TrkA-positive neurons were present in other vestibular-related brainstem regions (e.g. prepositus hypoglossal nucleus). In older rats (>P21), a strong immunostaining of TrkA was observed on both neuronal somata and nerve fibers within the lateral and spinal vestibular nuclei while no immunostaining was detected in the medial and superior vestibular nuclei and subnuclei. In the first few postnatal days, immunoreactivity for TrkB was virtually absent from the vestibular nuclei. At P4, a diffuse and very weak TrkB immunoreactivity was found restricted to cell bodies in the lateral and spinal vestibular nuclei as well as group y subnucleus. During the second postnatal week, the TrkB immunostaining became prominent throughout the vestibular nuclear complex. Extremely strong labelling was observed in the large-sized neurons. The intensity of TrkB immunostaining decreased to a moderate level at P21 and persisted until the adult stage. In contrast, immunoreactivity for TrkC within the vestibular nuclei was weak and diffuse during each of the postnatal ages studied. The differential expression pattern of these three neurotrophin receptors during development suggests a crucial role in the modulation of postnatal vestibular function.
Persistent Identifierhttp://hdl.handle.net/10722/105035

 

DC FieldValueLanguage
dc.contributor.authorChan, YSen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorYung, KKLen_HK
dc.date.accessioned2010-09-25T22:17:35Z-
dc.date.available2010-09-25T22:17:35Z-
dc.date.issued2001en_HK
dc.identifier.citationNeuroscience 2001, San Diego, CA, 10-15 November 2001. In Society for Neuroscience Abstracts, 2001, v. 27 n. 1, p. 788 Abstract no. 298.27en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105035-
dc.description.abstractNeurotrophins and their receptors are known to play an important role in neuronal development. Postnatal development of neurons immunoreactive for three neurotrophin receptor tyrosine kinases (TrkA, TrkB, and TrkC) was examined in the rat vestibular nuclei and subnuclei. TrkA immunoreactivity was not observed in these areas during the first two postnatal weeks, though some TrkA-positive neurons were present in other vestibular-related brainstem regions (e.g. prepositus hypoglossal nucleus). In older rats (>P21), a strong immunostaining of TrkA was observed on both neuronal somata and nerve fibers within the lateral and spinal vestibular nuclei while no immunostaining was detected in the medial and superior vestibular nuclei and subnuclei. In the first few postnatal days, immunoreactivity for TrkB was virtually absent from the vestibular nuclei. At P4, a diffuse and very weak TrkB immunoreactivity was found restricted to cell bodies in the lateral and spinal vestibular nuclei as well as group y subnucleus. During the second postnatal week, the TrkB immunostaining became prominent throughout the vestibular nuclear complex. Extremely strong labelling was observed in the large-sized neurons. The intensity of TrkB immunostaining decreased to a moderate level at P21 and persisted until the adult stage. In contrast, immunoreactivity for TrkC within the vestibular nuclei was weak and diffuse during each of the postnatal ages studied. The differential expression pattern of these three neurotrophin receptors during development suggests a crucial role in the modulation of postnatal vestibular function.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleExpression of neurotrophin receptors in vestibular nuclei during the postnatal development of the raten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.hkuros72035en_HK
dc.identifier.volume27en_HK
dc.identifier.spage29827en_HK

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