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Conference Paper: Melatonin modulates cAMP signaling in rat epididymal epithelial cells

TitleMelatonin modulates cAMP signaling in rat epididymal epithelial cells
Authors
Issue Date1998
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The FASEB Journal, 1998, v. 12 n. 5, p. A686, abstract no. 3982 How to Cite?
AbstractMelatonin, a pineal neurohormone, has been implicated in the regulation of a variety of biological processes such as circadian rhythmicities and reproductive functions. Our laboratory has successfully identified high affinity melatonin binding sites in the corpus epididymidis of rats. This observation has provided us with a unique opportunity to define the effects of melatonin on various signal transduction pathways in male reproductive tissues. The effects of melatonin on cAMP levels in rat corpus epididymis were investigated. Melatonin was found to inhibit, concentration-dependently, forskolin-stimulated cAMP accumulation in epididymal epithelial cells via pertussis toxin-sensitive Gi protein-coupled receptors. This inhibitory action of melatonin on forskolin-stimulated cAMP was potentiated by 5α-dihydrotestosterone. The stimulation of adenylyl cyclase by isoproterenol or norepinephrine was attenuated by melatonin. In situ hybridization studies have identified functional melatonin MEL1A and MEL1B receptors in rat epididymal epithelial cells. The effects of different melatonin analogues on adenylyl cyclase activity of rat epididymal epithelial cells were also studied. Our data support a modulatory action of melatonin, mediated via pertussis toxin-sensitive Gi-coupled MEL1A and MEL1B receptors, in the regulation of rat epididymal epithelial cell physiology.
Persistent Identifierhttp://hdl.handle.net/10722/105032
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLi, Len_HK
dc.contributor.authorXu, JNen_HK
dc.contributor.authorPang, SFen_HK
dc.contributor.authorShiu, SYWen_HK
dc.date.accessioned2010-09-25T22:17:27Z-
dc.date.available2010-09-25T22:17:27Z-
dc.date.issued1998en_HK
dc.identifier.citationThe FASEB Journal, 1998, v. 12 n. 5, p. A686, abstract no. 3982en_HK
dc.identifier.issn0892-6638en_HK
dc.identifier.urihttp://hdl.handle.net/10722/105032-
dc.description.abstractMelatonin, a pineal neurohormone, has been implicated in the regulation of a variety of biological processes such as circadian rhythmicities and reproductive functions. Our laboratory has successfully identified high affinity melatonin binding sites in the corpus epididymidis of rats. This observation has provided us with a unique opportunity to define the effects of melatonin on various signal transduction pathways in male reproductive tissues. The effects of melatonin on cAMP levels in rat corpus epididymis were investigated. Melatonin was found to inhibit, concentration-dependently, forskolin-stimulated cAMP accumulation in epididymal epithelial cells via pertussis toxin-sensitive Gi protein-coupled receptors. This inhibitory action of melatonin on forskolin-stimulated cAMP was potentiated by 5α-dihydrotestosterone. The stimulation of adenylyl cyclase by isoproterenol or norepinephrine was attenuated by melatonin. In situ hybridization studies have identified functional melatonin MEL1A and MEL1B receptors in rat epididymal epithelial cells. The effects of different melatonin analogues on adenylyl cyclase activity of rat epididymal epithelial cells were also studied. Our data support a modulatory action of melatonin, mediated via pertussis toxin-sensitive Gi-coupled MEL1A and MEL1B receptors, in the regulation of rat epididymal epithelial cell physiology.en_HK
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_HK
dc.relation.ispartofFASEB Journalen_HK
dc.titleMelatonin modulates cAMP signaling in rat epididymal epithelial cellsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0892-6638&volume=12&issue=5&spage=Abstract 3982&epage=&date=1998&atitle=Melatonin+modulates+cAMP+signaling+in+rat+epididymal+epithelial+cellsen_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-33745877383en_HK
dc.identifier.hkuros36813en_HK
dc.identifier.volume12en_HK
dc.identifier.issue5en_HK
dc.identifier.spageA686, abstract no. 3982en_HK
dc.identifier.epageA686, abstract no. 3982en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, L=36985954800en_HK
dc.identifier.scopusauthoridXu, JN=7407009328en_HK
dc.identifier.scopusauthoridPang, SF=7402528719en_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK

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