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Conference Paper: Synaptic regulation of glutamate receptor subunit composition in central vestibular neurons during neonatal development

TitleSynaptic regulation of glutamate receptor subunit composition in central vestibular neurons during neonatal development
Authors
Issue Date2006
PublisherSociety for Neuroscience
Citation
Neuroscience 2006, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 550.13/Y17 How to Cite?
AbstractTo investigate the functional role of ionotropic glutamate receptor subunits (AMPA and NMDA) in the development of central vestibular system, whole-cell patch-clamp experiments were performed in neurons within the spinal vestibular nucleus of neonatal (P1-9) rats. In each brainstem slice preparation, the profiles of AMPA receptor- and NMDA receptor-mediated currents were recorded from spinal vestibular nuclear neurons in response to electrical stimulation of the vestibular nerve. At P1-3, around 85% of the evoked excitatory postsynaptic current (eEPSC) was identified as NMDA receptor-mediated current while the remaining was AMPA receptor-mediated current. From P5 to P9, the NMDA component decreased from 70% to 52% while the AMPA component increased from 30% to 48%. These indicate that the contribution of AMPA receptors to eEPSC increased with age. With selective blockade of NR2B receptor subunit, NMDA receptor-mediated eEPSC was largely blocked before P5, indicating the significant contribution of NR2B subunit in spinal vestibular nuclear neurons of neonatal rats. On the other hand, NMDA receptor-mediated eEPSC on or after P7 was dominated by NR2A subunit component. Taken together, our findings provide evidence that change in AMPA and NMDA receptor subunits within glutamatergic synapses is important to the functional maturation of central vestibular neurons in postnatal rats.
Persistent Identifierhttp://hdl.handle.net/10722/105030

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChan, YS-
dc.date.accessioned2010-09-25T22:17:23Z-
dc.date.available2010-09-25T22:17:23Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuroscience 2006, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 550.13/Y17-
dc.identifier.urihttp://hdl.handle.net/10722/105030-
dc.description.abstractTo investigate the functional role of ionotropic glutamate receptor subunits (AMPA and NMDA) in the development of central vestibular system, whole-cell patch-clamp experiments were performed in neurons within the spinal vestibular nucleus of neonatal (P1-9) rats. In each brainstem slice preparation, the profiles of AMPA receptor- and NMDA receptor-mediated currents were recorded from spinal vestibular nuclear neurons in response to electrical stimulation of the vestibular nerve. At P1-3, around 85% of the evoked excitatory postsynaptic current (eEPSC) was identified as NMDA receptor-mediated current while the remaining was AMPA receptor-mediated current. From P5 to P9, the NMDA component decreased from 70% to 52% while the AMPA component increased from 30% to 48%. These indicate that the contribution of AMPA receptors to eEPSC increased with age. With selective blockade of NR2B receptor subunit, NMDA receptor-mediated eEPSC was largely blocked before P5, indicating the significant contribution of NR2B subunit in spinal vestibular nuclear neurons of neonatal rats. On the other hand, NMDA receptor-mediated eEPSC on or after P7 was dominated by NR2A subunit component. Taken together, our findings provide evidence that change in AMPA and NMDA receptor subunits within glutamatergic synapses is important to the functional maturation of central vestibular neurons in postnatal rats.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleSynaptic regulation of glutamate receptor subunit composition in central vestibular neurons during neonatal developmenten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros137722en_HK

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