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Conference Paper: Developmental changes in excitatory and inhibitory transmission at central vestibular synapses of rats

TitleDevelopmental changes in excitatory and inhibitory transmission at central vestibular synapses of rats
Authors
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
The 30th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 10–12 September 2007. In Neuroscience Research, 2007, v. 58 n. S1, p. S99 How to Cite?
AbstractSignal transmission in the adult vestibular nucleus (VN) is regulated by excitatory and inhibitory synapses. Little is known about synaptic activities in developing VN. Patch clamp recordings in VN neurons of postnatal rats revealed that both the number and amplitude of GABAergic miniature IPSC increased with age while the decay time decreased. Corresponding parameters of glutamatergic miniature EPSC (mEPSC) did not change with age. These mEPSCs were equally contributed by AMPA and NMDA components before P9 but were dominated by AMPA component at P21. For evoked EPSC (eEPSC), we observed a developmental decrease in NMDA component and a reciprocal increase in the quantal contribution of AMPA component. The reduction in NMDA-only synapses coincided with the increase in AMPA/NMDA ratio. We further found that NMDA receptor-mediated eEPSC was contributed predominantly by NR2B subunit in neonates but by NR2A subunit after P7. Our findings document changes in synaptic events during the maturation of VN neurons. Supported by HKRGC.
Persistent Identifierhttp://hdl.handle.net/10722/105019
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985

 

DC FieldValueLanguage
dc.contributor.authorChan, YSen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorYung, WHen_HK
dc.date.accessioned2010-09-25T22:16:56Z-
dc.date.available2010-09-25T22:16:56Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 30th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 10–12 September 2007. In Neuroscience Research, 2007, v. 58 n. S1, p. S99-
dc.identifier.issn0168-0102-
dc.identifier.urihttp://hdl.handle.net/10722/105019-
dc.description.abstractSignal transmission in the adult vestibular nucleus (VN) is regulated by excitatory and inhibitory synapses. Little is known about synaptic activities in developing VN. Patch clamp recordings in VN neurons of postnatal rats revealed that both the number and amplitude of GABAergic miniature IPSC increased with age while the decay time decreased. Corresponding parameters of glutamatergic miniature EPSC (mEPSC) did not change with age. These mEPSCs were equally contributed by AMPA and NMDA components before P9 but were dominated by AMPA component at P21. For evoked EPSC (eEPSC), we observed a developmental decrease in NMDA component and a reciprocal increase in the quantal contribution of AMPA component. The reduction in NMDA-only synapses coincided with the increase in AMPA/NMDA ratio. We further found that NMDA receptor-mediated eEPSC was contributed predominantly by NR2B subunit in neonates but by NR2A subunit after P7. Our findings document changes in synaptic events during the maturation of VN neurons. Supported by HKRGC.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures-
dc.relation.ispartofNeuroscience Researchen_HK
dc.titleDevelopmental changes in excitatory and inhibitory transmission at central vestibular synapses of ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailTse, YC: tseyc@hkusua.hku.hken_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neures.2007.06.1143-
dc.identifier.hkuros149738en_HK

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