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Conference Paper: Feed-forward modulation of the thalamocortical projections on different layers of the auditory cortex

TitleFeed-forward modulation of the thalamocortical projections on different layers of the auditory cortex
Authors
Issue Date2007
PublisherSociety for Neuroscience
Citation
Neuroscience 2007, San Diego, CA, 3-7 November 2007, Program#/Poster#: 278.6/EE5 How to Cite?
AbstractIn the present study, feedforward modulation of the thalamocortical projections on the auditory cortex was investigated. The neuronal responses of the cortical neurons to electrical stimulation of the medial geniculate body and auditory stimulus were recorded with both intracellular and extracellular recordings. A stimulation electrode array was implanted in the MGB targeting the medial and ventral divisions. Electrode array for extracellular recording was implanted in the auditory cortex, recording neuronal responses from different layers simultaneously, while a sharp glass electrode was advanced to record neurons intracellularly. The stimulation sites in the MGB were confirmed with electrical lesion, while the recording neurons were labeled with biocytin after physiology. Neurons in the auditory cortex showed spontaneous activities with occasional oscillatory activity. A synchronized activity among from different layers could be found when there was an oscillation. The oscillation propagated from deep layers to the surface layers. The auditory responses appeared at layers III and IV before reaching to layers II and I, and layers V and VI. Stimulation of the MGv evoked mainly excitatory output in layers II to V, while stimulation of the MGm evoked mainly long-lasting inhibitory effect on the neurons in the deep layers. The present results would contribute to our understanding information processing mechanisms of feed-forward thalamocortical pathways and interaction among the layers in the cortex.
Persistent Identifierhttp://hdl.handle.net/10722/104915

 

DC FieldValueLanguage
dc.contributor.authorWang, Nen_HK
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2010-09-25T22:12:42Z-
dc.date.available2010-09-25T22:12:42Z-
dc.date.issued2007en_HK
dc.identifier.citationNeuroscience 2007, San Diego, CA, 3-7 November 2007, Program#/Poster#: 278.6/EE5-
dc.identifier.urihttp://hdl.handle.net/10722/104915-
dc.description.abstractIn the present study, feedforward modulation of the thalamocortical projections on the auditory cortex was investigated. The neuronal responses of the cortical neurons to electrical stimulation of the medial geniculate body and auditory stimulus were recorded with both intracellular and extracellular recordings. A stimulation electrode array was implanted in the MGB targeting the medial and ventral divisions. Electrode array for extracellular recording was implanted in the auditory cortex, recording neuronal responses from different layers simultaneously, while a sharp glass electrode was advanced to record neurons intracellularly. The stimulation sites in the MGB were confirmed with electrical lesion, while the recording neurons were labeled with biocytin after physiology. Neurons in the auditory cortex showed spontaneous activities with occasional oscillatory activity. A synchronized activity among from different layers could be found when there was an oscillation. The oscillation propagated from deep layers to the surface layers. The auditory responses appeared at layers III and IV before reaching to layers II and I, and layers V and VI. Stimulation of the MGv evoked mainly excitatory output in layers II to V, while stimulation of the MGm evoked mainly long-lasting inhibitory effect on the neurons in the deep layers. The present results would contribute to our understanding information processing mechanisms of feed-forward thalamocortical pathways and interaction among the layers in the cortex.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleFeed-forward modulation of the thalamocortical projections on different layers of the auditory cortexen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.hkuros149814en_HK

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