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Conference Paper: Developmental expression of metabotropic glutamate receptor 1α in rat vestibular nuclear neurons responding to linear accelerations

TitleDevelopmental expression of metabotropic glutamate receptor 1α in rat vestibular nuclear neurons responding to linear accelerations
Authors
Issue Date2006
PublisherSociety for Neuroscience
Citation
Neuroscience 2006, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 550.9/Y13 How to Cite?
AbstractTo investigate the developmental expression of metabotropic glutamate receptor 1α (mGluR1α) in functionally activated otolith-related neurons within the vestibular nucleus, double-immunohistochemistry experiments were performed in conscious Sprague-Dawley rats (P4 to adult) subjected to sinusoidal linear acceleration along the vertical, horizontal transverse or horizontal antero-posterior plane. Neuronal activation was defined by the expression of c-fos in the vestibular nucleus. Labyrinthectomized and/or stationary controls showed only a few sporadically scattered Fos-labeled neurons, confirming the otolithic origin of expression in test animals. In response to linear acceleration in 3-D space, Fos/mGluR1α double-labeled neurons in adult rats were observed throughout the medial vestibular nucleus, spinal vestibular nucleus, the ventral part of the lateral vestibular nucleus, group x, and group y. The superior vestibular nucleus, however, was the only region within the vestibular nuclear complex where neurons were sensitive only to horizontal linear accelerations, i.e. 2-D spatial orientations. In P4-6 rats, no Fos-labeled neurons were found in the vestibular nuclei where immunoreactivity to mGluR1α was virtually absent. Fos/mGluR1α double-labeled neurons responsive to transverse or vertical stimulation were first observed at P7 while those to antero-posterior stimulation were first identified at P9. From P9 onwards, the number of Fos/mGluR1α double-labeled neurons responsive to stimulation along the horizontal or vertical axis increased with age and reached adult levels at P21. Our results suggest that mGluR1α in central otolith neurons might contribute to the developmental recognition of gravity-related spatial orientations.
Persistent Identifierhttp://hdl.handle.net/10722/104907

 

DC FieldValueLanguage
dc.contributor.authorLee, RWPen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorLai, CHen_HK
dc.date.accessioned2010-09-25T22:12:22Z-
dc.date.available2010-09-25T22:12:22Z-
dc.date.issued2006en_HK
dc.identifier.citationNeuroscience 2006, Atlanta, GA, 14-18 October 2006, Program#/Poster#: 550.9/Y13en_HK
dc.identifier.urihttp://hdl.handle.net/10722/104907-
dc.description.abstractTo investigate the developmental expression of metabotropic glutamate receptor 1α (mGluR1α) in functionally activated otolith-related neurons within the vestibular nucleus, double-immunohistochemistry experiments were performed in conscious Sprague-Dawley rats (P4 to adult) subjected to sinusoidal linear acceleration along the vertical, horizontal transverse or horizontal antero-posterior plane. Neuronal activation was defined by the expression of c-fos in the vestibular nucleus. Labyrinthectomized and/or stationary controls showed only a few sporadically scattered Fos-labeled neurons, confirming the otolithic origin of expression in test animals. In response to linear acceleration in 3-D space, Fos/mGluR1α double-labeled neurons in adult rats were observed throughout the medial vestibular nucleus, spinal vestibular nucleus, the ventral part of the lateral vestibular nucleus, group x, and group y. The superior vestibular nucleus, however, was the only region within the vestibular nuclear complex where neurons were sensitive only to horizontal linear accelerations, i.e. 2-D spatial orientations. In P4-6 rats, no Fos-labeled neurons were found in the vestibular nuclei where immunoreactivity to mGluR1α was virtually absent. Fos/mGluR1α double-labeled neurons responsive to transverse or vertical stimulation were first observed at P7 while those to antero-posterior stimulation were first identified at P9. From P9 onwards, the number of Fos/mGluR1α double-labeled neurons responsive to stimulation along the horizontal or vertical axis increased with age and reached adult levels at P21. Our results suggest that mGluR1α in central otolith neurons might contribute to the developmental recognition of gravity-related spatial orientations.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.titleDevelopmental expression of metabotropic glutamate receptor 1α in rat vestibular nuclear neurons responding to linear accelerationsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLee, RWP: lapson18@graduate.hku.hken_HK
dc.identifier.emailTse, YC: tseyc@hkusua.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.hkuros137721en_HK

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