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Conference Paper: Modulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats
Title | Modulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats |
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Authors | |
Issue Date | 2006 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/NSG |
Citation | The Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 120 How to Cite? |
Abstract | Parkinson’s disease (PD) is a serious motor disorder which
caused by a degeneration of dopaminergic neurons in the substantia
nigra (SN) of the basal ganglia. Neurokinins (NK) are a
group of neuropeptides that are affected after and/or involved in
the pathogenesis of Parkinson’s disease. Objectives of the present
study were to investigate the changes in expression of NK1 receptor
in different neuronal elements of the striatum after the onset
of PD using 6-hydroxydopamine-lesioned rat as an animal model.
In lesioned rats, up-regulation of NK1 proteins was generally
observed in the striatum by western blotting and immunofluorescence.
In addition, double immunofluorescence revealed that
NK1 immunoreactivity was primarily found in perikarya of striatal
interneurons, namely the cholinergic, nitric oxide synthasepositive
striatal interneurons. Interestingly, after lesion, a marked
internalization of NK1 immunoreactivity was found in cholinergic
interneurons in the lesioned striatum. The intensity of NK1
immunofluorescence was found to be increased in cholinergic
and NOS-immunoreactive striatal interneurons in the lesioned
striatum. The present results indicate that expression of NK1 receptor
is modulated in the striatum of the lesioned rats. The patterns
of expression of NK1 receptor in striatal interneuron subpopulations
are also modulated after dopamine denervation.
NK1 receptor may therefore involve in the neuroprotection of
Parkinson’s disease.
Acknowledgement: Support contributed by: Joint Research
Scheme, National Natural Science Foundation of China and
Research Grants Council of Hong Kong, 30218002 and
N_HKBU202/02. |
Persistent Identifier | http://hdl.handle.net/10722/104904 |
ISSN | 2016 Impact Factor: 6.143 2023 SCImago Journal Rankings: 0.458 |
DC Field | Value | Language |
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dc.contributor.author | Chan, WS | en_HK |
dc.contributor.author | Chen, L | en_HK |
dc.contributor.author | Chan, YS | en_HK |
dc.contributor.author | Yung, KK | en_HK |
dc.date.accessioned | 2010-09-25T22:12:15Z | - |
dc.date.available | 2010-09-25T22:12:15Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | The Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 120 | - |
dc.identifier.issn | 1424-862X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/104904 | - |
dc.description.abstract | Parkinson’s disease (PD) is a serious motor disorder which caused by a degeneration of dopaminergic neurons in the substantia nigra (SN) of the basal ganglia. Neurokinins (NK) are a group of neuropeptides that are affected after and/or involved in the pathogenesis of Parkinson’s disease. Objectives of the present study were to investigate the changes in expression of NK1 receptor in different neuronal elements of the striatum after the onset of PD using 6-hydroxydopamine-lesioned rat as an animal model. In lesioned rats, up-regulation of NK1 proteins was generally observed in the striatum by western blotting and immunofluorescence. In addition, double immunofluorescence revealed that NK1 immunoreactivity was primarily found in perikarya of striatal interneurons, namely the cholinergic, nitric oxide synthasepositive striatal interneurons. Interestingly, after lesion, a marked internalization of NK1 immunoreactivity was found in cholinergic interneurons in the lesioned striatum. The intensity of NK1 immunofluorescence was found to be increased in cholinergic and NOS-immunoreactive striatal interneurons in the lesioned striatum. The present results indicate that expression of NK1 receptor is modulated in the striatum of the lesioned rats. The patterns of expression of NK1 receptor in striatal interneuron subpopulations are also modulated after dopamine denervation. NK1 receptor may therefore involve in the neuroprotection of Parkinson’s disease. Acknowledgement: Support contributed by: Joint Research Scheme, National Natural Science Foundation of China and Research Grants Council of Hong Kong, 30218002 and N_HKBU202/02. | - |
dc.language | eng | en_HK |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/NSG | en_HK |
dc.relation.ispartof | NeuroSignals | en_HK |
dc.rights | NeuroSignals. Copyright © S Karger AG. | en_HK |
dc.title | Modulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1424-862X&volume=&spage=&epage=&date=2006&atitle=Modulation+in+expression+of+neurokinin+receptor+NK1+in+the+striatum+of+6-hydroxydopamine-lesioned+rats | en_HK |
dc.identifier.email | Chan, YS: yschan@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, YS=rp00318 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1159/000095356 | - |
dc.identifier.hkuros | 137688 | en_HK |
dc.identifier.issnl | 1424-862X | - |