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Conference Paper: Modulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats

TitleModulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned rats
Authors
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
The Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 120 How to Cite?
AbstractParkinson’s disease (PD) is a serious motor disorder which caused by a degeneration of dopaminergic neurons in the substantia nigra (SN) of the basal ganglia. Neurokinins (NK) are a group of neuropeptides that are affected after and/or involved in the pathogenesis of Parkinson’s disease. Objectives of the present study were to investigate the changes in expression of NK1 receptor in different neuronal elements of the striatum after the onset of PD using 6-hydroxydopamine-lesioned rat as an animal model. In lesioned rats, up-regulation of NK1 proteins was generally observed in the striatum by western blotting and immunofluorescence. In addition, double immunofluorescence revealed that NK1 immunoreactivity was primarily found in perikarya of striatal interneurons, namely the cholinergic, nitric oxide synthasepositive striatal interneurons. Interestingly, after lesion, a marked internalization of NK1 immunoreactivity was found in cholinergic interneurons in the lesioned striatum. The intensity of NK1 immunofluorescence was found to be increased in cholinergic and NOS-immunoreactive striatal interneurons in the lesioned striatum. The present results indicate that expression of NK1 receptor is modulated in the striatum of the lesioned rats. The patterns of expression of NK1 receptor in striatal interneuron subpopulations are also modulated after dopamine denervation. NK1 receptor may therefore involve in the neuroprotection of Parkinson’s disease. Acknowledgement: Support contributed by: Joint Research Scheme, National Natural Science Foundation of China and Research Grants Council of Hong Kong, 30218002 and N_HKBU202/02.
Persistent Identifierhttp://hdl.handle.net/10722/104904
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763

 

DC FieldValueLanguage
dc.contributor.authorChan, WSen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorYung, KKen_HK
dc.date.accessioned2010-09-25T22:12:15Z-
dc.date.available2010-09-25T22:12:15Z-
dc.date.issued2006en_HK
dc.identifier.citationThe Hong Kong Society of Neurosciences 24th Annual Scientific Meeting, Hong Kong, 13-14 January 2005. In Neurosignals, 2006, v. 15 n. 3, p. 120-
dc.identifier.issn1424-862Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/104904-
dc.description.abstractParkinson’s disease (PD) is a serious motor disorder which caused by a degeneration of dopaminergic neurons in the substantia nigra (SN) of the basal ganglia. Neurokinins (NK) are a group of neuropeptides that are affected after and/or involved in the pathogenesis of Parkinson’s disease. Objectives of the present study were to investigate the changes in expression of NK1 receptor in different neuronal elements of the striatum after the onset of PD using 6-hydroxydopamine-lesioned rat as an animal model. In lesioned rats, up-regulation of NK1 proteins was generally observed in the striatum by western blotting and immunofluorescence. In addition, double immunofluorescence revealed that NK1 immunoreactivity was primarily found in perikarya of striatal interneurons, namely the cholinergic, nitric oxide synthasepositive striatal interneurons. Interestingly, after lesion, a marked internalization of NK1 immunoreactivity was found in cholinergic interneurons in the lesioned striatum. The intensity of NK1 immunofluorescence was found to be increased in cholinergic and NOS-immunoreactive striatal interneurons in the lesioned striatum. The present results indicate that expression of NK1 receptor is modulated in the striatum of the lesioned rats. The patterns of expression of NK1 receptor in striatal interneuron subpopulations are also modulated after dopamine denervation. NK1 receptor may therefore involve in the neuroprotection of Parkinson’s disease. Acknowledgement: Support contributed by: Joint Research Scheme, National Natural Science Foundation of China and Research Grants Council of Hong Kong, 30218002 and N_HKBU202/02.-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofNeuroSignalsen_HK
dc.rightsNeuroSignals. Copyright © S Karger AG.en_HK
dc.titleModulation in expression of neurokinin receptor NK1 in the striatum of 6-hydroxydopamine-lesioned ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1424-862X&volume=&spage=&epage=&date=2006&atitle=Modulation+in+expression+of+neurokinin+receptor+NK1+in+the+striatum+of+6-hydroxydopamine-lesioned+ratsen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000095356-
dc.identifier.hkuros137688en_HK

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