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Conference Paper: Postnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of rats

TitlePostnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of rats
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
The 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S9 How to Cite?
AbstractGlutamate is a major excitatory neurotransmitter within the vestibular nucleus. We hypothesize that different classes of glutamate receptors mature with different time scales to result in the different postsynaptic responses observed with postnatal development. To address this, Sprague–Dawley rats (P5 to adult) were subjected to off-vertical axis rotation (OVAR), a scanning stimulus that sequentially activates all directional polarization of hair cells on the utricle. Functionally activated central vestibular neurons were identified by Fos immunoreactivity. These neurons were also evaluated for co-expression of NMDA (NR1) and AMPA (GluR1, GluR2, GluR2/3 or GluR4) receptor subunits. In control animals (both labyrinthectomized rats subjected to OVAR and normal rats kept stationary), only a few sporadic Fos-positive neurons were found in the vestibular nuclei complex, thus confirming the otolithic origin of Fos expression in the test animals. Utricle-related neurons were first found within the vestibular nuclei in P7 rats. Around 85% of Fos-positive neurons in the vestibular nuclear complex at P7 co-expressed NMDA and AMPA receptor subunits. This percentage decreased progressively with age until 70% in adults. Among the remaining Fos-positive neurons in each age group of the rats tested, twothird of them only expressed NR1 or AMPA receptor subunit and the remaining one-third did not express any of these ionotropic receptors. These findings provide the histological basis for cross-modulation of NMDA and AMPA receptors leading to change in synaptic efficiacy during maturation. Acknowledgement: Supported by HK RGC grant.
Persistent Identifierhttp://hdl.handle.net/10722/104892
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035

 

DC FieldValueLanguage
dc.contributor.authorTse, YCen_HK
dc.contributor.authorKui, CYen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorYung, KKen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:11:45Z-
dc.date.available2010-09-25T22:11:45Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S9en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/104892-
dc.description.abstractGlutamate is a major excitatory neurotransmitter within the vestibular nucleus. We hypothesize that different classes of glutamate receptors mature with different time scales to result in the different postsynaptic responses observed with postnatal development. To address this, Sprague–Dawley rats (P5 to adult) were subjected to off-vertical axis rotation (OVAR), a scanning stimulus that sequentially activates all directional polarization of hair cells on the utricle. Functionally activated central vestibular neurons were identified by Fos immunoreactivity. These neurons were also evaluated for co-expression of NMDA (NR1) and AMPA (GluR1, GluR2, GluR2/3 or GluR4) receptor subunits. In control animals (both labyrinthectomized rats subjected to OVAR and normal rats kept stationary), only a few sporadic Fos-positive neurons were found in the vestibular nuclei complex, thus confirming the otolithic origin of Fos expression in the test animals. Utricle-related neurons were first found within the vestibular nuclei in P7 rats. Around 85% of Fos-positive neurons in the vestibular nuclear complex at P7 co-expressed NMDA and AMPA receptor subunits. This percentage decreased progressively with age until 70% in adults. Among the remaining Fos-positive neurons in each age group of the rats tested, twothird of them only expressed NR1 or AMPA receptor subunit and the remaining one-third did not express any of these ionotropic receptors. These findings provide the histological basis for cross-modulation of NMDA and AMPA receptors leading to change in synaptic efficiacy during maturation. Acknowledgement: Supported by HK RGC grant.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.titlePostnatal co-expression of AMPA and NMDA receptors in utricle-related vestibular nuclear neurons of ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=370 Suppl&spage=S9&epage=&date=2004&atitle=Postnatal+co-expression+of+AMPA+and+NMDA+receptors+in+utricle-related+vestibular+nuclear+neurons+of+ratsen_HK
dc.identifier.emailTse, YC: tseyc@hkusua.hku.hken_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2004.09.001-
dc.identifier.hkuros106743en_HK
dc.identifier.volume370en_HK
dc.identifier.spageS9en_HK

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