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Conference Paper: Expression of GABAB receptor in vestibular nuclear neurons of rats

TitleExpression of GABAB receptor in vestibular nuclear neurons of rats
Authors
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
The 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S10-S11 How to Cite?
AbstractGABAergic transmission is involved in both cerebellar and commissural inhibition of vestibular nuclear neurons. To locate the metabotropic GABAB receptor subunits in the vestibular nucleus, we immunostained for GABABR1 and GABABR2 in the medulla of adult Sprague–Dawley rats. In some experiments, off-vertical axis rotation, a scanning stimulus which sequentially stimulates all receptor hair cells on the utricle, was used to functionally activate Fos expression in vestibular nuclear neurons. Nearly all utriclerelated Fos immunopositive neurons expressed GABABR1 or GABABR2-immunoreactivity. Furthermore, double immunoreactivities of GABABR1 and GABABR2 were found in neuropilar elements as well as perikarya of neurons in the vestibular nuclei. These neurons were frequently associated with glutamic acid decarboxylase (GAD) immunopostive terminal-like puncta. Such puncta were so numerous in the dorsal lateral vestibular nucleus that they often outlined the soma. Within the vestibular nuclear complex, neurons that co-expressed GABABR1/GAD or GABABR2/GADimmunoreactivity were only found in the spinal vestibular nucleus. This constituted about 50% of the GABABR1 or GABABR2 immunopositive neurons in the spinal vestibular nucleus. Our findings therefore provide immunocytochemical evidence for the occurrence of heterodimeric GABAB receptor on GAD-containing neurons and utricle-related neurons in the rat vestibular nuclear complex. Acknowledgement: Supported by HK RGC.
Persistent Identifierhttp://hdl.handle.net/10722/104886
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035

 

DC FieldValueLanguage
dc.contributor.authorNg, KYen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T22:11:29Z-
dc.date.available2010-09-25T22:11:29Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 23rd Scientific Meeting of the Hong Kong Society of Neurosciences. Hong Kong, 2004. In Neuroscience Letters, 2004, v. 370 n. supplement, p. S10-S11en_HK
dc.identifier.issn0304-3940en_HK
dc.identifier.urihttp://hdl.handle.net/10722/104886-
dc.description.abstractGABAergic transmission is involved in both cerebellar and commissural inhibition of vestibular nuclear neurons. To locate the metabotropic GABAB receptor subunits in the vestibular nucleus, we immunostained for GABABR1 and GABABR2 in the medulla of adult Sprague–Dawley rats. In some experiments, off-vertical axis rotation, a scanning stimulus which sequentially stimulates all receptor hair cells on the utricle, was used to functionally activate Fos expression in vestibular nuclear neurons. Nearly all utriclerelated Fos immunopositive neurons expressed GABABR1 or GABABR2-immunoreactivity. Furthermore, double immunoreactivities of GABABR1 and GABABR2 were found in neuropilar elements as well as perikarya of neurons in the vestibular nuclei. These neurons were frequently associated with glutamic acid decarboxylase (GAD) immunopostive terminal-like puncta. Such puncta were so numerous in the dorsal lateral vestibular nucleus that they often outlined the soma. Within the vestibular nuclear complex, neurons that co-expressed GABABR1/GAD or GABABR2/GADimmunoreactivity were only found in the spinal vestibular nucleus. This constituted about 50% of the GABABR1 or GABABR2 immunopositive neurons in the spinal vestibular nucleus. Our findings therefore provide immunocytochemical evidence for the occurrence of heterodimeric GABAB receptor on GAD-containing neurons and utricle-related neurons in the rat vestibular nuclear complex. Acknowledgement: Supported by HK RGC.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_HK
dc.relation.ispartofNeuroscience Lettersen_HK
dc.rightsNeuroscience Letters. Copyright © Elsevier Ireland Ltd.en_HK
dc.titleExpression of GABAB receptor in vestibular nuclear neurons of ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=370 Supp&spage=S10&epage=11&date=2004&atitle=Expression+of+GABAB+receptors+in+vestibular+nuclear+neurons+of+ratsen_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neulet.2004.09.001-
dc.identifier.hkuros107301en_HK
dc.identifier.volume370en_HK
dc.identifier.spageS10en_HK
dc.identifier.epageS11en_HK

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