File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: The occurrence of Polyomavirus (BK Virus and its Variants) Transplant Nephropathy in Hong Kong and Macau

TitleThe occurrence of Polyomavirus (BK Virus and its Variants) Transplant Nephropathy in Hong Kong and Macau
Authors
Issue Date2008
PublisherWiley-Blackwell Publishing Asia. The Journals' website is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797
Citation
The 11th Asian Pacific Congress of Nephrology (APCN 2008), incorporating the 15th Asian Colloquium in Nephrology and 2nd Asian Forum of CKD Initiative, Kuala Lumpur, Malaysia, 5-8 May 2008. In Nephrology, 2008, v. 13 suppl. S1, p. A80, abstract no. 142 How to Cite?
AbstractIntroduction: BK virus is anephrotrophic polyomavirus that emerges as an important cause of graft dysfunction and failure. The reported incidence of BK virus nephropathy (BKvN) among transplant centers is variable. Our experience of BKvN in a single center is presented. Patients: Renal biopsies archived from 1990 to 2007 in Department of Pathology, Queen Mary Hospital were searched for cases of polyomavirus nephropathy. Selected were 9 graft biopsies from 6 patients. The first patient was from our own hospital and the diagnosis was made in 2005. Two patients were managed in a private hospital in Hong Kong. Biopsies from three patients were referred from a hospital in Macau in 2007. The selected biopsies and clinical features were reviewed. Diagnosis in 5 patients was based on virus-induced cytopathic changes and immunohistochemistry. For one patient, diagnosis was hampered by the negative immunoreactivity of the virus variant to a commercial antibody (Chemicon). The diagnosis was established instead by electron microscopy and detection of viral genome in biopsy tissue. This patient lost the graft kidney 6 months after the initial biopsy. Discussions: Despite the ubiquity of BK virus, we have encountered our first and only case of BKvN of our transplant center two and a half years back. The recent emergence and apparent clustering of cases suggest that some iatrogenic predisposing factors might be involved. The occurrence of virus variants may greatly affects the immunohistochemical detection of viral antigens, which is currently the most important method to diagnose BKvN.
DescriptionPoster Abstracts
Persistent Identifierhttp://hdl.handle.net/10722/104413
ISSN
2015 Impact Factor: 1.796
2015 SCImago Journal Rankings: 0.894

 

DC FieldValueLanguage
dc.contributor.authorChan, KWen_HK
dc.contributor.authorChan, GSWen_HK
dc.date.accessioned2010-09-25T21:52:04Z-
dc.date.available2010-09-25T21:52:04Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 11th Asian Pacific Congress of Nephrology (APCN 2008), incorporating the 15th Asian Colloquium in Nephrology and 2nd Asian Forum of CKD Initiative, Kuala Lumpur, Malaysia, 5-8 May 2008. In Nephrology, 2008, v. 13 suppl. S1, p. A80, abstract no. 142-
dc.identifier.issn1320-5358-
dc.identifier.urihttp://hdl.handle.net/10722/104413-
dc.descriptionPoster Abstracts-
dc.description.abstractIntroduction: BK virus is anephrotrophic polyomavirus that emerges as an important cause of graft dysfunction and failure. The reported incidence of BK virus nephropathy (BKvN) among transplant centers is variable. Our experience of BKvN in a single center is presented. Patients: Renal biopsies archived from 1990 to 2007 in Department of Pathology, Queen Mary Hospital were searched for cases of polyomavirus nephropathy. Selected were 9 graft biopsies from 6 patients. The first patient was from our own hospital and the diagnosis was made in 2005. Two patients were managed in a private hospital in Hong Kong. Biopsies from three patients were referred from a hospital in Macau in 2007. The selected biopsies and clinical features were reviewed. Diagnosis in 5 patients was based on virus-induced cytopathic changes and immunohistochemistry. For one patient, diagnosis was hampered by the negative immunoreactivity of the virus variant to a commercial antibody (Chemicon). The diagnosis was established instead by electron microscopy and detection of viral genome in biopsy tissue. This patient lost the graft kidney 6 months after the initial biopsy. Discussions: Despite the ubiquity of BK virus, we have encountered our first and only case of BKvN of our transplant center two and a half years back. The recent emergence and apparent clustering of cases suggest that some iatrogenic predisposing factors might be involved. The occurrence of virus variants may greatly affects the immunohistochemical detection of viral antigens, which is currently the most important method to diagnose BKvN.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journals' website is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797-
dc.relation.ispartofNephrologyen_HK
dc.titleThe occurrence of Polyomavirus (BK Virus and its Variants) Transplant Nephropathy in Hong Kong and Macauen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.emailChan, GSW: chanswg@HKUCC.hku.hken_HK
dc.identifier.doi10.1111/j.1440-1797.2008.00954.x-
dc.identifier.hkuros143489en_HK
dc.identifier.volume13-
dc.identifier.issuesuppl. S1-
dc.identifier.spageA80, abstract no. 142-
dc.identifier.epageA80, abstract no. 142-
dc.publisher.placeAustralia-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats