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Conference Paper: Identification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China

TitleIdentification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern China
Authors
Issue Date2007
PublisherInternational Medical Press Ltd.
Citation
The 2007 International Scientific Conference of Options for the Control of Influenza (Options-6), Toronto, ON., Canada, 17-23 June 2007. In Conference Proceedings, 2007, p. 400-402 How to Cite?
AbstractThe transmission of highly pathogenic avian influenza (HPAI) H5N1 virus to Southeast Asian countries triggered the first outbreak wave of this virus in late 2003. Subsequently H5N1 influenza virus has become endemic in poultry in this region, which has lead to the sustained transmission of those viruses and repeated outbreaks in poultry and human infection cases. This situation has raised global concern of a coming influenza pandemic sometime in the near future. Although surveillance work in market poultry had been strengthened following this initial outbreak in Southeast Asian countries, the lack of influenza surveillance prior to the outbreaks made it difficult to identify the precursors and transmission pathways of those H5N1 viruses. To determine the possible source of those H5N1 viruses responsible for this first transmission wave we recently conducted further sequencing of samples collected in live-poultry markets from Guangdong, Hunan and Yunnan Provinces in southern China from 2001 to 2003. Phylogenetic analysis of the HA gene of 50 H5N1 isolates from this period indicated that eight viruses, exclusively from Yunnan, fell as the direct progenitor to viruses isolated from Vietnam. A further two viruses isolated from Hunan were the direct precursor to those viruses from Indonesia. In general, phylogenetic analysis revealed similar relationships for the NA gene and each of the 6 internal genes, indicating that these viruses also belonged to the same H5N1 genotype Z that is predominant throughout Southeast Asia. These results clearly show a transmission of H5N1 viruses from Yunnan to Vietnam and from Hunan to Indonesia. Trade of poultry may be the major route of virus transmission between Yunnan and Vietnam, while the transmission route from Hunan to Indonesia remains unclear and could be either via migratory birds or poultry movement.
DescriptionPoster Presentations - Genetic and Antigenic Evolution
Persistent Identifierhttp://hdl.handle.net/10722/103279
ISBN

 

DC FieldValueLanguage
dc.contributor.authorWang, Jen_HK
dc.contributor.authorSmith, GJen_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorDuan, Len_HK
dc.contributor.authorDhanasekaran, Ven_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2010-09-25T21:05:44Z-
dc.date.available2010-09-25T21:05:44Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 2007 International Scientific Conference of Options for the Control of Influenza (Options-6), Toronto, ON., Canada, 17-23 June 2007. In Conference Proceedings, 2007, p. 400-402-
dc.identifier.isbn978-1-901-769-15-6-
dc.identifier.urihttp://hdl.handle.net/10722/103279-
dc.descriptionPoster Presentations - Genetic and Antigenic Evolution-
dc.description.abstractThe transmission of highly pathogenic avian influenza (HPAI) H5N1 virus to Southeast Asian countries triggered the first outbreak wave of this virus in late 2003. Subsequently H5N1 influenza virus has become endemic in poultry in this region, which has lead to the sustained transmission of those viruses and repeated outbreaks in poultry and human infection cases. This situation has raised global concern of a coming influenza pandemic sometime in the near future. Although surveillance work in market poultry had been strengthened following this initial outbreak in Southeast Asian countries, the lack of influenza surveillance prior to the outbreaks made it difficult to identify the precursors and transmission pathways of those H5N1 viruses. To determine the possible source of those H5N1 viruses responsible for this first transmission wave we recently conducted further sequencing of samples collected in live-poultry markets from Guangdong, Hunan and Yunnan Provinces in southern China from 2001 to 2003. Phylogenetic analysis of the HA gene of 50 H5N1 isolates from this period indicated that eight viruses, exclusively from Yunnan, fell as the direct progenitor to viruses isolated from Vietnam. A further two viruses isolated from Hunan were the direct precursor to those viruses from Indonesia. In general, phylogenetic analysis revealed similar relationships for the NA gene and each of the 6 internal genes, indicating that these viruses also belonged to the same H5N1 genotype Z that is predominant throughout Southeast Asia. These results clearly show a transmission of H5N1 viruses from Yunnan to Vietnam and from Hunan to Indonesia. Trade of poultry may be the major route of virus transmission between Yunnan and Vietnam, while the transmission route from Hunan to Indonesia remains unclear and could be either via migratory birds or poultry movement.-
dc.languageengen_HK
dc.publisherInternational Medical Press Ltd.-
dc.relation.ispartofOptions for the Control of Influenza VI: Proceedings of the International Conference on Options for the Control of Influenza VI held in Toronto, Ontario, Canada, June 17-23, 2007en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleIdentification of precursors of Indonesia and Vietnam avian influenza A (H5N1) viruses from southern Chinaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWang, J: crystal165@sohu.comen_HK
dc.identifier.emailSmith, GJ: gjsmith@HKUCC.hku.hken_HK
dc.identifier.emailDuan, L: dlhku@hkucc.hku.hken_HK
dc.identifier.emailDhanasekaran, V: veejay.here@gmail.comen_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authoritySmith, GJ=rp00444en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturepostprint-
dc.identifier.hkuros132215en_HK
dc.identifier.spage400-
dc.identifier.epage402-
dc.publisher.placeUnited States-

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