File Download

There are no files associated with this item.

Conference Paper: Expression of Avian Influenza Virus Receptors and H5N1 Virus Infection In Human Respiratory Tract

TitleExpression of Avian Influenza Virus Receptors and H5N1 Virus Infection In Human Respiratory Tract
Authors
Issue Date2007
PublisherInternational Medical Press Ltd.
Citation
The 2007 International Scientific Conference of Options for the Control of Influenza (Options-6), Toronto, ON., Canada, 17-23 June 2007. In Conference Proceedings, 2007, p. 66-69 How to Cite?
AbstractReceptor specificity restricts influenza virus cross species transmission, with SAα2,6 Gal and SAα2,3 Gal sialic acids recognized by human and avian influenza viruses, respectively. This study investigated the distribution of these two species of sialic acids in the human respiratory tract. The SAα2,3 Gal species was infrequently detected in the upper respiratory tract, but prevalent in the lower part, while the SAα2,6 Gal species is more common in the upper respiratory tract. Though alveolus cells are more susceptible than trachea and bronchus epithelial cells to avian influenza H5N1 virus infection in the ex vivo experiment, H5N1 virus was found to infect the upper respiratory tract epithelial cells of a human case. It was also found that H5N1 virus infection occurs in the epithelial cells of the respiratory tract which do not express detectable SA α2,3Gal. These observations may be important to investigate further if the currently-observed limited human to human transmission by H5N1 virus is associated with the differential expression of SAα2,3 Gal in human upper respiratory tract among individuals.
DescriptionOral Presentations - Virus Structure/Function and Receptor Binding
Persistent Identifierhttp://hdl.handle.net/10722/103190
ISBN

 

DC FieldValueLanguage
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorZhang, Zen_HK
dc.contributor.authorFang, Xen_HK
dc.contributor.authorHuang, Ken_HK
dc.contributor.authorRayner, JMen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorLi, KSen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorChen, Hen_HK
dc.date.accessioned2010-09-25T21:01:56Z-
dc.date.available2010-09-25T21:01:56Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 2007 International Scientific Conference of Options for the Control of Influenza (Options-6), Toronto, ON., Canada, 17-23 June 2007. In Conference Proceedings, 2007, p. 66-69en_HK
dc.identifier.isbn978-1-901-769-15-6-
dc.identifier.urihttp://hdl.handle.net/10722/103190-
dc.descriptionOral Presentations - Virus Structure/Function and Receptor Binding-
dc.description.abstractReceptor specificity restricts influenza virus cross species transmission, with SAα2,6 Gal and SAα2,3 Gal sialic acids recognized by human and avian influenza viruses, respectively. This study investigated the distribution of these two species of sialic acids in the human respiratory tract. The SAα2,3 Gal species was infrequently detected in the upper respiratory tract, but prevalent in the lower part, while the SAα2,6 Gal species is more common in the upper respiratory tract. Though alveolus cells are more susceptible than trachea and bronchus epithelial cells to avian influenza H5N1 virus infection in the ex vivo experiment, H5N1 virus was found to infect the upper respiratory tract epithelial cells of a human case. It was also found that H5N1 virus infection occurs in the epithelial cells of the respiratory tract which do not express detectable SA α2,3Gal. These observations may be important to investigate further if the currently-observed limited human to human transmission by H5N1 virus is associated with the differential expression of SAα2,3 Gal in human upper respiratory tract among individuals.-
dc.languageengen_HK
dc.publisherInternational Medical Press Ltd.-
dc.relation.ispartofOptions for the Control of Influenza VI: Proceedings of the International Conference on Options for the Control of Influenza VI held in Toronto, Ontario, Canada, June 17-23, 2007en_HK
dc.titleExpression of Avian Influenza Virus Receptors and H5N1 Virus Infection In Human Respiratory Tracten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailZhang, J: zhangajx@hotmail.comen_HK
dc.identifier.emailZhang, Z: zfzhangphd@163.comen_HK
dc.identifier.emailHuang, K: h0794012@hkusua.hku.hken_HK
dc.identifier.emailRayner, JM: raynerj2002@yahoo.comen_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.authorityZhang, J=rp00413en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.hkuros130523en_HK
dc.identifier.spage66en_HK
dc.identifier.epage69-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats