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Conference Paper: Naturally occurring antiviral drug resistance in avian H5N1 virus

TitleNaturally occurring antiviral drug resistance in avian H5N1 virus
Authors
Issue Date2007
PublisherInternational Medical Press Ltd.
Citation
The 2007 International Scientific Conference of Options for the Control of Influenza (Options-6), Toronto, ON., Canada, 17-23 June 2007. In Conference Proceedings, 2007, p. 154-156 How to Cite?
AbstractResistance to the neuraminidase inhibitor, oseltamivir, was found in H5N1 virus isolated from infected patients in Vietnam but no recent avian H5N1 isolates have been reported to possess known neuraminidase inhibitor resistance mutations. It is still not clear whether the NA1 gene neuraminidase mutation, His274Tyr, detected in H5N1 infected human cases originated during disease treatment or came from the avian virus source. A 2002 HK chicken H5N1 isolate was found to contain the His274Tyr mutation on NA1 and resistance to oseltamivir was confirmed using a cell-based assay. To investigate if His274Tyr might naturally occur at low levels mixed with wild type in H5N1 poultry infections we examined isolates from different hosts and geographical locations using a differential RT-PCR assay. The His274Ty quasi species was more frequently recognized in isolates from infected chickens than in isolates from ducks and geese, but no geographical difference was observed. Close surveillance of mutants in the virus population, combined with pursuit of alternative therapies, is essential to H5N1 pandemic containment strategies.
DescriptionOral Presentations - Antivirals and Resistance
Persistent Identifierhttp://hdl.handle.net/10722/103119
ISBN

 

DC FieldValueLanguage
dc.contributor.authorRayner, JMen_HK
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorSmith, GJen_HK
dc.contributor.authorWang, Pen_HK
dc.contributor.authorTai, Hen_HK
dc.contributor.authorSong, Wen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorChen, Hen_HK
dc.date.accessioned2010-09-25T20:58:47Z-
dc.date.available2010-09-25T20:58:47Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 2007 International Scientific Conference of Options for the Control of Influenza (Options-6), Toronto, ON., Canada, 17-23 June 2007. In Conference Proceedings, 2007, p. 154-156-
dc.identifier.isbn978-1-901-769-15-6-
dc.identifier.urihttp://hdl.handle.net/10722/103119-
dc.descriptionOral Presentations - Antivirals and Resistance-
dc.description.abstractResistance to the neuraminidase inhibitor, oseltamivir, was found in H5N1 virus isolated from infected patients in Vietnam but no recent avian H5N1 isolates have been reported to possess known neuraminidase inhibitor resistance mutations. It is still not clear whether the NA1 gene neuraminidase mutation, His274Tyr, detected in H5N1 infected human cases originated during disease treatment or came from the avian virus source. A 2002 HK chicken H5N1 isolate was found to contain the His274Tyr mutation on NA1 and resistance to oseltamivir was confirmed using a cell-based assay. To investigate if His274Tyr might naturally occur at low levels mixed with wild type in H5N1 poultry infections we examined isolates from different hosts and geographical locations using a differential RT-PCR assay. The His274Ty quasi species was more frequently recognized in isolates from infected chickens than in isolates from ducks and geese, but no geographical difference was observed. Close surveillance of mutants in the virus population, combined with pursuit of alternative therapies, is essential to H5N1 pandemic containment strategies.-
dc.languageengen_HK
dc.publisherInternational Medical Press Ltd.-
dc.relation.ispartofOptions for the Control of Influenza VI: Proceedings of the International Conference on Options for the Control of Influenza VI held in Toronto, Ontario, Canada, June 17-23, 2007en_HK
dc.titleNaturally occurring antiviral drug resistance in avian H5N1 virusen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailRayner, JM: raynerj2002@yahoo.comen_HK
dc.identifier.emailCheung, CL: 50169944@plink.cityu.edu.hken_HK
dc.identifier.emailSmith, GJ: gjsmith@HKUCC.hku.hken_HK
dc.identifier.emailWang, P: puiwang@hkucc.hku.hken_HK
dc.identifier.emailTai, H: barttai@graduate.hku.hken_HK
dc.identifier.emailSong, W: dbsswj@nus.edu.sgen_HK
dc.identifier.emailZhang, J: zhangajx@hotmail.comen_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.authoritySmith, GJ=rp00444en_HK
dc.identifier.authorityZhang, J=rp00413en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.hkuros132390en_HK
dc.identifier.spage154-
dc.identifier.epage156-
dc.publisher.placeUnited States-

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