File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Impaired serum cholesterol efflux potential is associated with endothelial dysfunction in type 2 diabetic patients

TitleImpaired serum cholesterol efflux potential is associated with endothelial dysfunction in type 2 diabetic patients
Authors
Issue Date2006
PublisherHong Kong Academy of Medicine
Citation
The 4th International Huaxia Congress of Endocrinology, Hong Kong, 15–18 December 2006. In Hong Kong Medical Journal, 2006, v. 12 n. 6 S4, p. 150 Abstract no. P170 How to Cite?
AbstractObjective: Cellular cholesterol efflux to serum is the first step in reverse cholesterol transport and plays an important role in reducing the accumulation of excess cholesterol in arterial wall and prevents atherosclerosis. This study was performed to investigate whether abnormalities in serum cholesterol efflux potential were related to endothelial dysfunction in type 2 diabetic patients. Methods: 95 type 2 diabetic patients and 19 age-matched healthy controls were recruited. Endothelium-dependent vasodilation (EDVD) and endothelium-independent vasodilation (EIDVD) of the brachial artery were measured by high-resolution vascular ultrasound. Serum cholesterol efflux potential was determined by measuring the transfer of [3 H] cholesterol from SR-BI rich Fu5AH cells to the medium induced by the test serum. Results: Type 2 diabetic patients had significantly lower HDL than controls. Serum cholesterol efflux potential was reduced in diabetic patients (15.0±2.0 vs. 18.5±2.6%, P<0.001), and both EDVD (5.2±2.5 vs. 7.4±3.3%, P=0.001) and EIDVD (13.4±4.5 vs. 15.7±4.2%, P=0.045) were also impaired compared with controls. Serum cholesterol efflux potential correlated with both EDVD (r=0.23, P=0.02) and EIDVD (r=0.24, P=0.02) in diabetic patients. On multiple regression analysis of all subjects (including age, gender, the presence of diabetes, smoking status, body mass index, waist, blood pressure, triglyceride, LDL and serum cholesterol efflux potential), only serum cholesterol efflux potential remained a significant independent determinant of EDVD (r 2 =0.15, P<0.001). Serum cholesterol efflux potential was not an independent determinant of EIDVD. Conclusion: Impaired serum cholesterol efflux potential is related to endothelial dysfunction independent of other cardiovascular risk factors.
Persistent Identifierhttp://hdl.handle.net/10722/102958
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorZhou, Hen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorWong, Yen_HK
dc.contributor.authorTan, KCBen_HK
dc.date.accessioned2010-09-25T20:51:47Z-
dc.date.available2010-09-25T20:51:47Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 4th International Huaxia Congress of Endocrinology, Hong Kong, 15–18 December 2006. In Hong Kong Medical Journal, 2006, v. 12 n. 6 S4, p. 150 Abstract no. P170-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/102958-
dc.description.abstractObjective: Cellular cholesterol efflux to serum is the first step in reverse cholesterol transport and plays an important role in reducing the accumulation of excess cholesterol in arterial wall and prevents atherosclerosis. This study was performed to investigate whether abnormalities in serum cholesterol efflux potential were related to endothelial dysfunction in type 2 diabetic patients. Methods: 95 type 2 diabetic patients and 19 age-matched healthy controls were recruited. Endothelium-dependent vasodilation (EDVD) and endothelium-independent vasodilation (EIDVD) of the brachial artery were measured by high-resolution vascular ultrasound. Serum cholesterol efflux potential was determined by measuring the transfer of [3 H] cholesterol from SR-BI rich Fu5AH cells to the medium induced by the test serum. Results: Type 2 diabetic patients had significantly lower HDL than controls. Serum cholesterol efflux potential was reduced in diabetic patients (15.0±2.0 vs. 18.5±2.6%, P<0.001), and both EDVD (5.2±2.5 vs. 7.4±3.3%, P=0.001) and EIDVD (13.4±4.5 vs. 15.7±4.2%, P=0.045) were also impaired compared with controls. Serum cholesterol efflux potential correlated with both EDVD (r=0.23, P=0.02) and EIDVD (r=0.24, P=0.02) in diabetic patients. On multiple regression analysis of all subjects (including age, gender, the presence of diabetes, smoking status, body mass index, waist, blood pressure, triglyceride, LDL and serum cholesterol efflux potential), only serum cholesterol efflux potential remained a significant independent determinant of EDVD (r 2 =0.15, P<0.001). Serum cholesterol efflux potential was not an independent determinant of EIDVD. Conclusion: Impaired serum cholesterol efflux potential is related to endothelial dysfunction independent of other cardiovascular risk factors.-
dc.languageengen_HK
dc.publisherHong Kong Academy of Medicine-
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.titleImpaired serum cholesterol efflux potential is associated with endothelial dysfunction in type 2 diabetic patientsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailShiu, SWM: swmshiu@HKUSUA.hku.hken_HK
dc.identifier.emailWong, Y: ywong@HKUCC-COM.hku.hken_HK
dc.identifier.emailTan, KCB: kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.identifier.hkuros131675en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats