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Conference Paper: Familial Aggregation in Constipated Subjects in a Tertiary Referral Center

TitleFamilial Aggregation in Constipated Subjects in a Tertiary Referral Center
Authors
Issue Date2006
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Gastroenterology, 2006, v. 130 n. 4 Suppl 2, p. A-159-A-160 Abstract no. S1131 How to Cite?
AbstractBackground: Clinical observation showed that there is family aggregation in constipated subjects, but formal data are lacking. This prompted us to conduct a formal family study in constipated subjects Methods: Constipated subjects (probands) were identified according to the Rome II and Chinese constipation questionnaire criteria, healthy subjects were chosen as controls. Living first degree relatives (parents, siblings and children) and spouses from both groups were identified. The questionnaire on Rome II criteria was given to the relatives either through the index subjects or by mail. The questionnaire was received by mailing back or through the index subjects. Any non-responders were chased. Results: There were 132 probands with constipation and 114 controls identified. The Rome II questionnaire was sent to a total of 677 relatives of the probands and 591 of the controls. The respond rate was 100%. Relatives were comparable in mean age, sex distribution, family size and marital status in the two groups. Constipation prevalence was 16.4% in probands’ relatives versus 9.1% in controls’ relatives (p < 0.001). Among them, only 6% vs 9.3% of the relatives reporting constipation were spouses of the probands and controls (p=0.5). Probands’ relatives were at increase risk to have constipation than controls’ (odds ratio 1.86 for at least one member with constipation ((CI) 1.11, 3.14), odds ratio 3.54 for two or more member with constipation (CI: 1.71, 7.36)). Conclusions: Familial aggregation of constipation occurs, supporting a genetic or intrafamilial environment component.
Persistent Identifierhttp://hdl.handle.net/10722/102954
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorChan, OOen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorHu, HCen_HK
dc.contributor.authorLeung, Gen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorYuen, RMFen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T20:51:37Z-
dc.date.available2010-09-25T20:51:37Z-
dc.date.issued2006en_HK
dc.identifier.citationGastroenterology, 2006, v. 130 n. 4 Suppl 2, p. A-159-A-160 Abstract no. S1131en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/102954-
dc.description.abstractBackground: Clinical observation showed that there is family aggregation in constipated subjects, but formal data are lacking. This prompted us to conduct a formal family study in constipated subjects Methods: Constipated subjects (probands) were identified according to the Rome II and Chinese constipation questionnaire criteria, healthy subjects were chosen as controls. Living first degree relatives (parents, siblings and children) and spouses from both groups were identified. The questionnaire on Rome II criteria was given to the relatives either through the index subjects or by mail. The questionnaire was received by mailing back or through the index subjects. Any non-responders were chased. Results: There were 132 probands with constipation and 114 controls identified. The Rome II questionnaire was sent to a total of 677 relatives of the probands and 591 of the controls. The respond rate was 100%. Relatives were comparable in mean age, sex distribution, family size and marital status in the two groups. Constipation prevalence was 16.4% in probands’ relatives versus 9.1% in controls’ relatives (p < 0.001). Among them, only 6% vs 9.3% of the relatives reporting constipation were spouses of the probands and controls (p=0.5). Probands’ relatives were at increase risk to have constipation than controls’ (odds ratio 1.86 for at least one member with constipation ((CI) 1.11, 3.14), odds ratio 3.54 for two or more member with constipation (CI: 1.71, 7.36)). Conclusions: Familial aggregation of constipation occurs, supporting a genetic or intrafamilial environment component.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titleFamilial Aggregation in Constipated Subjects in a Tertiary Referral Centeren_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=130 &issue=4 Suppl 2&spage=A&epage=159&date=2006&atitle=Familial+Aggregation+in+Constipated+Subjects+in+a+Tertiary+Referral+Centeren_HK
dc.identifier.emailChan, OO: aoochan@hku.hken_HK
dc.identifier.emailHui, WM: hrmehwm@hkucc.hku.hken_HK
dc.identifier.emailHu, HC: hchu@HKUCC.hku.hken_HK
dc.identifier.emailChan, CK: ckchanj@HKUCC-COM.hku.hken_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.doi10.1016/S0016-5085(06)60008-5-
dc.identifier.hkuros116860en_HK
dc.identifier.volume130en_HK
dc.identifier.issue4 Suppl 2en_HK
dc.identifier.epage159en_HK

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