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Conference Paper: Polyma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm

TitlePolyma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm
Authors
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
The 2005 Roche Asian Transplantation and Immunology Forum, Jeju, Korea, 2005. In Bone Marrow Transplant, 2005, v. 36 n. 11, p. 929-937 How to Cite?
AbstractHaemorrhagic cystitis (HC) is a distinct clinical disorder of multiple aetiologies. It is characterized by painful haematuria due to haemorrhagic inflammation of the urinary bladder mucosa. In allogeneic haematopoietic stem cell transplantation (HSCT), HC occurring before engraftment is mostly transient and self-limiting, whereas that after engraftment is severe and sometimes life-threatening. Pre- and post-engraftment HC represent distinct disorders with different aetiologies and treatment implications. Recent data suggest that reactivation of the polyoma BK virus (BKV) plays a pivotal role in post-engraftment HC. Urotoxicity of the conditioning regimen and alloimmune reaction accompanying graft-versus-host disease (GVHD) upon engraftment are also important pathogenetic factors. Based on data from BKV studies, we propose that HC may be divided into three phases. In the first phase, the conditioning regimen damages uroepithelial cells, providing a milieu for BKV replication. In the second phase, unchecked uroepithelial BKV replication leads to BK viruria. In the last phase after engraftment, alloimmunity against BKV-infected uroepithelial cells leads to HC. The quinolone antibiotics suppress BKV replication in vivo and in vitro, suggesting that their prophylactic use may prevent the occurrence of HC.
Persistent Identifierhttp://hdl.handle.net/10722/102708
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585

 

DC FieldValueLanguage
dc.contributor.authorLeung, AYH-
dc.contributor.authorYuen, KY-
dc.contributor.authorKwong, YL-
dc.date.accessioned2010-09-25T20:41:36Z-
dc.date.available2010-09-25T20:41:36Z-
dc.date.issued2005-
dc.identifier.citationThe 2005 Roche Asian Transplantation and Immunology Forum, Jeju, Korea, 2005. In Bone Marrow Transplant, 2005, v. 36 n. 11, p. 929-937-
dc.identifier.issn0268-3369-
dc.identifier.urihttp://hdl.handle.net/10722/102708-
dc.description.abstractHaemorrhagic cystitis (HC) is a distinct clinical disorder of multiple aetiologies. It is characterized by painful haematuria due to haemorrhagic inflammation of the urinary bladder mucosa. In allogeneic haematopoietic stem cell transplantation (HSCT), HC occurring before engraftment is mostly transient and self-limiting, whereas that after engraftment is severe and sometimes life-threatening. Pre- and post-engraftment HC represent distinct disorders with different aetiologies and treatment implications. Recent data suggest that reactivation of the polyoma BK virus (BKV) plays a pivotal role in post-engraftment HC. Urotoxicity of the conditioning regimen and alloimmune reaction accompanying graft-versus-host disease (GVHD) upon engraftment are also important pathogenetic factors. Based on data from BKV studies, we propose that HC may be divided into three phases. In the first phase, the conditioning regimen damages uroepithelial cells, providing a milieu for BKV replication. In the second phase, unchecked uroepithelial BKV replication leads to BK viruria. In the last phase after engraftment, alloimmunity against BKV-infected uroepithelial cells leads to HC. The quinolone antibiotics suppress BKV replication in vivo and in vitro, suggesting that their prophylactic use may prevent the occurrence of HC.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt-
dc.relation.ispartofBone Marrow Transplantation-
dc.subject.meshBK Virus - physiology-
dc.subject.meshCystitis - etiology/prevention & control - virology-
dc.subject.meshHematopoietic Stem Cell Transplantation - adverse effects-
dc.subject.meshHumans-
dc.subject.meshPolyomavirus Infections - drug therapy - etiology-
dc.subject.meshPolyomavirus Infections/drug therapy - etiology-
dc.subject.meshTumor Virus Infections/drug therapy - etiology-
dc.subject.meshVirus Activation-
dc.titlePolyma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm-
dc.typeConference_Paper-
dc.identifier.emailLeung, AYH: ayhleung@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hku.hk-
dc.identifier.emailKwong, YL: ylkwong@hku.hk-
dc.identifier.authorityLeung, AYH=rp00265-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityKwong, YL=rp00358-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.bmt.1705139-
dc.identifier.pmid16184185-
dc.identifier.hkuros99049-
dc.identifier.volume36-
dc.identifier.issue11-
dc.identifier.spage929-
dc.identifier.epage937-
dc.publisher.placeUnited Kingdom-

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