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Conference Paper: Efficacy of Tegaserod for Functional Constipation in Chinese Subjects: A Randomized Double Blind Controlled Trial in a Single Center

TitleEfficacy of Tegaserod for Functional Constipation in Chinese Subjects: A Randomized Double Blind Controlled Trial in a Single Center
Authors
Issue Date2007
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Digestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute, Washington, DC, 19-24 May 2007. In Gastroenterology, 2007, v. 132 n. 4, p. A-194 Abstract no. S1199 How to Cite?
AbstractBackground: Tegaserod has been shown to be effective in chronic constipation in western population. Aim: We investigated if Tegaserod is equally effective in Chinese population. Materials and methods: 250 patients were randomized to a double-blinded 8-week treatment of Tegaserod 6mg b.i.d or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowl motion (CSBM)≥1/ week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: 109 patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs 29% for the treatment and placebo groups (p=0.005). The sustained CSBM rate was 29.4% vs 15.7% in the two groups (p=0.016). The response rate was higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating, and satisfaction of bowel habit (ps<0.05). The mental score was higher in the treatment group (46.8±9 vs 43.6±10, p=0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in western population.
Persistent Identifierhttp://hdl.handle.net/10722/102562
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorLeung, YCen_HK
dc.contributor.authorHu, HCen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T20:35:39Z-
dc.date.available2010-09-25T20:35:39Z-
dc.date.issued2007en_HK
dc.identifier.citationDigestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute, Washington, DC, 19-24 May 2007. In Gastroenterology, 2007, v. 132 n. 4, p. A-194 Abstract no. S1199en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/102562-
dc.description.abstractBackground: Tegaserod has been shown to be effective in chronic constipation in western population. Aim: We investigated if Tegaserod is equally effective in Chinese population. Materials and methods: 250 patients were randomized to a double-blinded 8-week treatment of Tegaserod 6mg b.i.d or placebo. Response during weeks 1-4 was defined as an increase in complete spontaneous bowl motion (CSBM)≥1/ week. Secondary efficacy included response during weeks 1-8, individual symptoms and scores, quality of life and global assessment of bowel habits and constipation. Results: 109 patients from the treatment group and 107 from the placebo group completed the 8-week treatment. Responder rates was 47.7% vs 29% for the treatment and placebo groups (p=0.005). The sustained CSBM rate was 29.4% vs 15.7% in the two groups (p=0.016). The response rate was higher than that reported previously in the Caucasian studies. There was improvement in the scores for stool form scale, bothersomeness of constipation, abdominal distension/bloating, and satisfaction of bowel habit (ps<0.05). The mental score was higher in the treatment group (46.8±9 vs 43.6±10, p=0.01). Conclusions: Tegaserod is effective in relieving chronic constipation in Chinese population. The efficacy observed may be higher than that in western population.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titleEfficacy of Tegaserod for Functional Constipation in Chinese Subjects: A Randomized Double Blind Controlled Trial in a Single Centeren_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=132&issue=4&spage=A194&epage=&date=2007&atitle=Efficacy+of+tegasered+for+functiona+constipation+in+Chinese+subjects:+A+randomized+double+blind+contolled+trial+in+a+single+center.++Digestive+Disease+Week+2007,+Washington+DC,+USA,+19-24+Mayen_HK
dc.identifier.emailChan, AOO: aoochan@hku.hken_HK
dc.identifier.emailHui, WM: hrmehwm@hkucc.hku.hken_HK
dc.identifier.emailLeung, YC: newgigi21@hotmail.comen_HK
dc.identifier.emailHu, HC: hchu@HKUCC.hku.hken_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0016-5085(07)60009-2-
dc.identifier.hkuros131419en_HK
dc.identifier.volume132en_HK
dc.identifier.issue4en_HK
dc.identifier.spage194en_HK

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