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Conference Paper: The n-3 polyunsaturated fatty acids from fish oil inhibit transient outward and ultra-rapid delayed rectifier potassium currents and voltage-gated sodium current in human atrial myocytes

TitleThe n-3 polyunsaturated fatty acids from fish oil inhibit transient outward and ultra-rapid delayed rectifier potassium currents and voltage-gated sodium current in human atrial myocytes
Authors
Issue Date2007
PublisherOxford University Press
Citation
CardioRhythm 2007, Hong Kong, 2-4 February 2007. In Europace, 2007, v. 9 n. S1, p. 25 How to Cite?
AbstractBackground and Objectives: There is growing clinical evidence that the n-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have antiarrhythmic effects (including anti-atrial fibrillation) in humans; however, their ionic mechanisms are not fully understood. The aim of the present study was to investigate the effects of n-3 PUFAs from fish oil on transient outward and ultra-rapid delayed rectifier potassium currents (Ito and IKur), and voltage-gated sodium current (INa) in human atrial myocytes. Methods: Cardiac myocytes were enzymatically isolated from human atrial specimens from patients undergoing coronary artery bypass operation. Ito, IKur, and INa were recorded using whole-cell patch configuration. Result: EPA and DHA inhibited Ito in a concentration-dependent manner (IC50: 5.1 mM for EPA; 3.8 mM mM for DHA), positively shifted voltage-dependent-activation of the current. In addition, the unique current IKur was suppressed by 1 –50 mM EPA (IC50: 11.3 mM) and DHA (IC50: 3.5 mM) in human atrial cells. Moreover, EPA and DHA also reduced INa in human atrial myocytes in a concentration-dependent manner (IC50: 10.7 mM for EPA; 13.7 mM for DHA), negatively shifted the potential of INa availability, and slowed recovery of INa from inactivation. Conclusions: The present study demonstrates the novel information that EPA and DHA inhibit Ito, IKur, and INa in human atrial myocytes in a concentration-dependent manner, and these effects likely contribute at least in part to anti-atrial fibrillation of n-3 PUFAs in humans.
Persistent Identifierhttp://hdl.handle.net/10722/102524
ISSN
2015 Impact Factor: 4.021
2015 SCImago Journal Rankings: 2.201

 

DC FieldValueLanguage
dc.contributor.authorLi, GRen_HK
dc.contributor.authorSun, Hen_HK
dc.contributor.authorTang, Qen_HK
dc.contributor.authorChiu, SWen_HK
dc.contributor.authorLau, CP-
dc.date.accessioned2010-09-25T20:34:08Z-
dc.date.available2010-09-25T20:34:08Z-
dc.date.issued2007en_HK
dc.identifier.citationCardioRhythm 2007, Hong Kong, 2-4 February 2007. In Europace, 2007, v. 9 n. S1, p. 25en_HK
dc.identifier.issn1099-5129-
dc.identifier.urihttp://hdl.handle.net/10722/102524-
dc.description.abstractBackground and Objectives: There is growing clinical evidence that the n-3 polyunsaturated fatty acids (n-3 PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have antiarrhythmic effects (including anti-atrial fibrillation) in humans; however, their ionic mechanisms are not fully understood. The aim of the present study was to investigate the effects of n-3 PUFAs from fish oil on transient outward and ultra-rapid delayed rectifier potassium currents (Ito and IKur), and voltage-gated sodium current (INa) in human atrial myocytes. Methods: Cardiac myocytes were enzymatically isolated from human atrial specimens from patients undergoing coronary artery bypass operation. Ito, IKur, and INa were recorded using whole-cell patch configuration. Result: EPA and DHA inhibited Ito in a concentration-dependent manner (IC50: 5.1 mM for EPA; 3.8 mM mM for DHA), positively shifted voltage-dependent-activation of the current. In addition, the unique current IKur was suppressed by 1 –50 mM EPA (IC50: 11.3 mM) and DHA (IC50: 3.5 mM) in human atrial cells. Moreover, EPA and DHA also reduced INa in human atrial myocytes in a concentration-dependent manner (IC50: 10.7 mM for EPA; 13.7 mM for DHA), negatively shifted the potential of INa availability, and slowed recovery of INa from inactivation. Conclusions: The present study demonstrates the novel information that EPA and DHA inhibit Ito, IKur, and INa in human atrial myocytes in a concentration-dependent manner, and these effects likely contribute at least in part to anti-atrial fibrillation of n-3 PUFAs in humans.-
dc.languageengen_HK
dc.publisherOxford University Press-
dc.relation.ispartofEuropaceen_HK
dc.titleThe n-3 polyunsaturated fatty acids from fish oil inhibit transient outward and ultra-rapid delayed rectifier potassium currents and voltage-gated sodium current in human atrial myocytesen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLi, GR: grli@hkucc.hku.hken_HK
dc.identifier.emailSun, H: hysun@hkucc.hku.hken_HK
dc.identifier.emailChiu, SW: swchiu@HKUCC.hku.hken_HK
dc.identifier.emailLau, CP: cplau@hku.hken_HK
dc.identifier.authorityLi, GR=rp00476en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/europace/eul156-
dc.identifier.hkuros131094en_HK
dc.identifier.volume9en_HK
dc.identifier.issueS1en_HK
dc.identifier.spage25en_HK

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