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Conference Paper: Effect Of The Microsomal Triglyceride Transfer Protein –493 G/T Polymorphism And Type 2 Diabetes Mellitus On LDL Subfractions

TitleEffect Of The Microsomal Triglyceride Transfer Protein –493 G/T Polymorphism And Type 2 Diabetes Mellitus On LDL Subfractions
Authors
Issue Date2003
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org
Citation
The 8th Medical Research Conference of Department of Medicine, The University of Hong Kong, Hong Kong, 25 – 26 January 2003. In Hong Kong Medical Journal, 2003, v. 9 n. S1, p. 36 How to Cite?
AbstractIntroduction. Genetic variation in the microsomal triglyceride transfer protein (MTP) affects the secretion pattern and plasma concentration of apolipoprotein (aopB)-containing lipoproteins and the common functional –493 G/T polymorphism has been reported to influence plasma lipids levels. Recent data suggest that carriers of the T allele might be more sensitive to detrimental factor such as features of the insulin resistance syndrome. Since type 2 diabetes is associated with obesity and insulin resistance, the present study investigated the effect of this polymorphism on plasma lipids, apoB and LDL subfractions in 281 Chinese type 2 diabetic patients and 364 non-diabetic controls. Methods. The polymorphism for each subject was determined by polymerase chain reaction, restriction enzymatic action and subsequent electrophoresis on 3% metaphor agarose gel. Results. The frequency of the rare T allele was 0.162 and 0.126 in subjects with and without diabetes respectively. Diabetic subjects had significant higher body mass index and waist hip ratio than the controls (p<0.01). There were no differences in the effect of the polymorphism on plasma lipids and apoB in the 2 groups. However, the TT genotype was associated with a higher concentration of small dense LDL-III than the GT or GG variants in the diabetic subjects (p = 0.01) whereas no such effect was observed in the controls. In the diabetic patients, age, plasma triglyceride and the MTP genotype were independent determinants of LDL-III concentrations in linear regression analysis (R2 = 10%, p <0.05) whereas in the controls, only plasma triglyceride and age were important determinants (R2 = 15%, p <0.01). Conclusion. The -493 G/T polymorphism has a minor effect on LDL subfraction pattern in Chinese and the effect is only apparent in the presence of type 2 diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/102464
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorChen, SPLen_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-25T20:31:42Z-
dc.date.available2010-09-25T20:31:42Z-
dc.date.issued2003en_HK
dc.identifier.citationThe 8th Medical Research Conference of Department of Medicine, The University of Hong Kong, Hong Kong, 25 – 26 January 2003. In Hong Kong Medical Journal, 2003, v. 9 n. S1, p. 36-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/102464-
dc.description.abstractIntroduction. Genetic variation in the microsomal triglyceride transfer protein (MTP) affects the secretion pattern and plasma concentration of apolipoprotein (aopB)-containing lipoproteins and the common functional –493 G/T polymorphism has been reported to influence plasma lipids levels. Recent data suggest that carriers of the T allele might be more sensitive to detrimental factor such as features of the insulin resistance syndrome. Since type 2 diabetes is associated with obesity and insulin resistance, the present study investigated the effect of this polymorphism on plasma lipids, apoB and LDL subfractions in 281 Chinese type 2 diabetic patients and 364 non-diabetic controls. Methods. The polymorphism for each subject was determined by polymerase chain reaction, restriction enzymatic action and subsequent electrophoresis on 3% metaphor agarose gel. Results. The frequency of the rare T allele was 0.162 and 0.126 in subjects with and without diabetes respectively. Diabetic subjects had significant higher body mass index and waist hip ratio than the controls (p<0.01). There were no differences in the effect of the polymorphism on plasma lipids and apoB in the 2 groups. However, the TT genotype was associated with a higher concentration of small dense LDL-III than the GT or GG variants in the diabetic subjects (p = 0.01) whereas no such effect was observed in the controls. In the diabetic patients, age, plasma triglyceride and the MTP genotype were independent determinants of LDL-III concentrations in linear regression analysis (R2 = 10%, p <0.05) whereas in the controls, only plasma triglyceride and age were important determinants (R2 = 15%, p <0.01). Conclusion. The -493 G/T polymorphism has a minor effect on LDL subfraction pattern in Chinese and the effect is only apparent in the presence of type 2 diabetes.-
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org-
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.titleEffect Of The Microsomal Triglyceride Transfer Protein –493 G/T Polymorphism And Type 2 Diabetes Mellitus On LDL Subfractionsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTan, KCB: kcbtan@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.hkuros78401en_HK

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