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Conference Paper: Association of Interferon-gamma (IFN-g) Polymorphisms with Susceptibility of Hepatitis B Virus (HBV) Infection in the Hong Kong Chinese

TitleAssociation of Interferon-gamma (IFN-g) Polymorphisms with Susceptibility of Hepatitis B Virus (HBV) Infection in the Hong Kong Chinese
Authors
Issue Date2007
PublisherNature Publishing Group
Citation
European Human Genetics Conference 2007, Nice, France, 16 - 19 June 2007. In European Journal of Human Genetics, 2007, v. 15 n. S1, p. 253 Abstract no. P0990 How to Cite?
AbstractBackground: Hepatitis B virus (HBV) infection is the most common cause of acute hepatitis and may progress to chronic liver disease, including cirrhosis or hepatocellular carcinoma (HCC). Host genetic factors are important for this progression. Interferon-gamma (IFN-γ) is a pro-inflammatory T-helper 1 (Th1) cytokine. It plays crucial roles in downregulation of HBV replication and its clearance.1 Serum IFN-γ levels were lower in the chronic hepatitis B patients than the normal controls, supporting that IFN-γ is involved in the progression of HBV infection.2 Objective: We aimed to determine whether a functional single nucleotide polymorphism (SNP) of IFN-γ may affect the susceptibility of HBV infection in Hong Kong Chinese population. Methods: We recruited 460 chronic HBV carriers and 87 individuals who had spontaneously recovered from HBV infection as evidenced by the presence of anti-HBs and anti-HBc antibodies. The SNP of IFN- γ at +874 A/T at intron 1 at the 5’ end of a CA repeat microsatellite sequence was detected using Genescan analysis. Results: For the spontaneous recovered individuals, the genotype frequencies were 54.0% for A/A, 39.1% for A/T and 6.9% for T/T. For the chronic HBV carriers, the genotype frequencies were 72.8% for A/A, 24.6% for A/T and 2.6% for T/T. The A/A genotype was predominant in the chronic carriers (odd ratio=4.09, CI=1.35-12.4), and its frequency was significantly higher than those with spontaneous recovery after adjusting for age and gender (p<0.0001). Conclusion: The polymorphism of IFN-γ gene at position +874 may confer susceptibility to persistent HBV infection. References: 1. Rehermann B et al. (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immun. 5: 215-27 2. Akpolat N et al. (2005) Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B. World J Gastroenterol. 11 (21):3260-3
Persistent Identifierhttp://hdl.handle.net/10722/102427
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLee, WYen_HK
dc.contributor.authorLee, PPWen_HK
dc.contributor.authorWong, WHen_HK
dc.contributor.authorYuen, RMFen_HK
dc.contributor.authorPoon, RTPen_HK
dc.contributor.authorLau, YL-
dc.date.accessioned2010-09-25T20:30:12Z-
dc.date.available2010-09-25T20:30:12Z-
dc.date.issued2007en_HK
dc.identifier.citationEuropean Human Genetics Conference 2007, Nice, France, 16 - 19 June 2007. In European Journal of Human Genetics, 2007, v. 15 n. S1, p. 253 Abstract no. P0990-
dc.identifier.issn1476-5438-
dc.identifier.urihttp://hdl.handle.net/10722/102427-
dc.description.abstractBackground: Hepatitis B virus (HBV) infection is the most common cause of acute hepatitis and may progress to chronic liver disease, including cirrhosis or hepatocellular carcinoma (HCC). Host genetic factors are important for this progression. Interferon-gamma (IFN-γ) is a pro-inflammatory T-helper 1 (Th1) cytokine. It plays crucial roles in downregulation of HBV replication and its clearance.1 Serum IFN-γ levels were lower in the chronic hepatitis B patients than the normal controls, supporting that IFN-γ is involved in the progression of HBV infection.2 Objective: We aimed to determine whether a functional single nucleotide polymorphism (SNP) of IFN-γ may affect the susceptibility of HBV infection in Hong Kong Chinese population. Methods: We recruited 460 chronic HBV carriers and 87 individuals who had spontaneously recovered from HBV infection as evidenced by the presence of anti-HBs and anti-HBc antibodies. The SNP of IFN- γ at +874 A/T at intron 1 at the 5’ end of a CA repeat microsatellite sequence was detected using Genescan analysis. Results: For the spontaneous recovered individuals, the genotype frequencies were 54.0% for A/A, 39.1% for A/T and 6.9% for T/T. For the chronic HBV carriers, the genotype frequencies were 72.8% for A/A, 24.6% for A/T and 2.6% for T/T. The A/A genotype was predominant in the chronic carriers (odd ratio=4.09, CI=1.35-12.4), and its frequency was significantly higher than those with spontaneous recovery after adjusting for age and gender (p<0.0001). Conclusion: The polymorphism of IFN-γ gene at position +874 may confer susceptibility to persistent HBV infection. References: 1. Rehermann B et al. (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immun. 5: 215-27 2. Akpolat N et al. (2005) Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B. World J Gastroenterol. 11 (21):3260-3-
dc.languageengen_HK
dc.publisherNature Publishing Group-
dc.relation.ispartofEuropean Journal of Human Geneticsen_HK
dc.titleAssociation of Interferon-gamma (IFN-g) Polymorphisms with Susceptibility of Hepatitis B Virus (HBV) Infection in the Hong Kong Chineseen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLee, WY: h0226204@hkusua.hku.hken_HK
dc.identifier.emailLee, PPW: ppwlee@hku.hken_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailPoon, RTP: poontp@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hkucc.hku.hken_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.authorityPoon, RTP=rp00446en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.hkuros131026en_HK

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