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Conference Paper: Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles

TitleNon-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles
Authors
Issue Date2004
PublisherWiley-Blackwell Publishing Asia
Citation
The 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, 10-13 December 2004. In Respirology, 2004, v. 9 n. S3, p. A114 Abstract no. 033 How to Cite?
AbstractIntroduction Lung cancer, mainly consists of non-small cell carcinoma (NSCLC), has become an epidemic in the past few decades. Recent data have suggested an important role of antioxidants and reactive oxygen species in lung carcinogenesis. However, the exact antioxidant profiles in subjects with NSCLC are lacking. We have conducted a study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects. Method Antioxidants (catalase, superoxide dismutase [SOD], and glutathione peroxidase [GPx]) were measured using chemical kinetic reactions under spectrophotometry as previously described.1 Results There were 189 cases of mostly advanced stage IIIB or IV NSCLC (67% males, 57.0 ± 11.7 years, 56% ever-smoked, 56% adenocarcinoma) and 202 healthy controls (59% males, 49.5 ± 15.6 years, 39% ever-smoked) being studied. In subjects with lung cancer, there were higher catalase activity (32.6 ± 4.3 vs 23.5 ± 0.9 mU/g haemoglobin (Hb), P = 0.03), lower SOD activity (26.4 ± 2.4 vs 55 ± 2.5 U/gHb, P < 0.001), and higher GPx activity (227.3 ± 12.4 vs 50.8 ± 1.1 mU/gHb, P < 0.001) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, gender, smoking status, or tumour cell types. However, more advanced disease (stage IV compared to IIIB) was associated with lower SOD activity (21.8 ± 2.5 vs 37.0 ± 5.7 U/gHb respectively, P = 0.03). Using multivariate analysis, the presence of lung cancer independently predicts catalase, SOD, and GPx activities. Conclusion NSCLC in Chinese is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. (This study is partially funded by the University Department of Medicine Research Grant 2002, the University of Hong Kong.)
Persistent Identifierhttp://hdl.handle.net/10722/101785
ISSN
2015 Impact Factor: 3.078
2015 SCImago Journal Rankings: 1.157

 

DC FieldValueLanguage
dc.contributor.authorHo, JCMen_HK
dc.contributor.authorHo, SPen_HK
dc.contributor.authorChan-Yeung, MMWen_HK
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorKo, KWen_HK
dc.contributor.authorYan, CPKen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2010-09-25T20:04:17Z-
dc.date.available2010-09-25T20:04:17Z-
dc.date.issued2004en_HK
dc.identifier.citationThe 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, 10-13 December 2004. In Respirology, 2004, v. 9 n. S3, p. A114 Abstract no. 033en_HK
dc.identifier.issn1323-7799-
dc.identifier.urihttp://hdl.handle.net/10722/101785-
dc.description.abstractIntroduction Lung cancer, mainly consists of non-small cell carcinoma (NSCLC), has become an epidemic in the past few decades. Recent data have suggested an important role of antioxidants and reactive oxygen species in lung carcinogenesis. However, the exact antioxidant profiles in subjects with NSCLC are lacking. We have conducted a study of the systemic antioxidant activities in red blood cell lysate from subjects with NSCLC and healthy control subjects. Method Antioxidants (catalase, superoxide dismutase [SOD], and glutathione peroxidase [GPx]) were measured using chemical kinetic reactions under spectrophotometry as previously described.1 Results There were 189 cases of mostly advanced stage IIIB or IV NSCLC (67% males, 57.0 ± 11.7 years, 56% ever-smoked, 56% adenocarcinoma) and 202 healthy controls (59% males, 49.5 ± 15.6 years, 39% ever-smoked) being studied. In subjects with lung cancer, there were higher catalase activity (32.6 ± 4.3 vs 23.5 ± 0.9 mU/g haemoglobin (Hb), P = 0.03), lower SOD activity (26.4 ± 2.4 vs 55 ± 2.5 U/gHb, P < 0.001), and higher GPx activity (227.3 ± 12.4 vs 50.8 ± 1.1 mU/gHb, P < 0.001) compared with controls. The antioxidant activities in lung cancer subjects were not associated with age, gender, smoking status, or tumour cell types. However, more advanced disease (stage IV compared to IIIB) was associated with lower SOD activity (21.8 ± 2.5 vs 37.0 ± 5.7 U/gHb respectively, P = 0.03). Using multivariate analysis, the presence of lung cancer independently predicts catalase, SOD, and GPx activities. Conclusion NSCLC in Chinese is associated with alterations in systemic antioxidant activities, which may play an important role in carcinogenesis. (This study is partially funded by the University Department of Medicine Research Grant 2002, the University of Hong Kong.)-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia-
dc.relation.ispartofRespirologyen_HK
dc.titleNon-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profilesen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailHo, JCM: jhocm@hku.hken_HK
dc.identifier.emailChan, MMW: mmwchan@hku.hken_HK
dc.identifier.emailMak, JCW: judymak@HKUCC.hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.emailYan, CPK: cpkyan@HKUSUA.hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailTsang, KWT: kwttsang@hku.hken_HK
dc.identifier.emailLam, WK: lamwk@hku.hken_HK
dc.identifier.authorityHo, JCM=rp00258en_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1843.2004.00673.x-
dc.identifier.hkuros98142en_HK
dc.identifier.volume9en_HK
dc.identifier.issueS3en_HK
dc.identifier.spageA114en_HK

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