File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: ESR1 CA(n) repeat polymorphism is associated with increased risk of osteoporotic fractures and estrogen receptor alpha: mrna expression in bone

TitleESR1 CA(n) repeat polymorphism is associated with increased risk of osteoporotic fractures and estrogen receptor alpha: mrna expression in bone
Authors
Issue Date2006
PublisherSpringer-Verlag
Citation
IOF World Congress on Osteoporosis, Toronto, Canada, 2-6 June 2006. In Osteoporosis International, 2006, v. 17 n. S2, p. S344 Abstract no. P746SU How to Cite?
AbstractIntroduction: Recent studies have shown that intronic CA dinucleotide repeat polymorphisms may be associated with disease risk by modulating mRNA splicing efficiency. D6S440 is a newly identified intronic CA repeat polymorphism located downstream of the 5’-splicing site of exon 5 of estrogen receptor alpha gene (ESR1). Methods: To evaluate the role of D6S440 in bone mineral density (BMD) determination and osteoporosis outcomes prediction, 281 pairs of premenopausal and 395 pairs of postmenopausal Chinese female case-control subjects were studied. The functional significance of D6S440 in determining estrogen receptor (ER ) gene expression was examined in human bone. Results: Post- but not premenopausal women with less CA repeats had lower BMD at both spine and hip. A linear relationship was seen between the number of CA repeats and hip BMD in postmenopausal women (;=0.008; p=0.004). Postmenopausal women with less than 18 CA repeats had higher risks of osteoporosis at the spine (odds ratio (OR) 2.46, 95% confidence interval (CI) 1.30–4.65; p=0.0006) and hip (OR 3.79(1.64–8.74), p=0.0002), and also increased risk of spine and hip fractures (OR 2.31(1.29–4.14), p=0.005). Perimenopausal women with CA repeat size <18 had significantly greater bone loss at the hip (-1.96%) than those with CA repeat size R18 (-1.61%; p=0.029) during 18 months of observation. Subjects with fewer CA repeats had reduced ER mRNA expression in their bone cells. Conclusions: ESR1 CA repeat polymorphism is associated with multiple osteoporosis outcomes and mRNA expression in bone, and this may be a useful genetic marker for fracture risk assessment.
Persistent Identifierhttp://hdl.handle.net/10722/101763
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460

 

DC FieldValueLanguage
dc.contributor.authorLai, MHen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2010-09-25T20:03:22Z-
dc.date.available2010-09-25T20:03:22Z-
dc.date.issued2006en_HK
dc.identifier.citationIOF World Congress on Osteoporosis, Toronto, Canada, 2-6 June 2006. In Osteoporosis International, 2006, v. 17 n. S2, p. S344 Abstract no. P746SU-
dc.identifier.issn0937-941X-
dc.identifier.urihttp://hdl.handle.net/10722/101763-
dc.description.abstractIntroduction: Recent studies have shown that intronic CA dinucleotide repeat polymorphisms may be associated with disease risk by modulating mRNA splicing efficiency. D6S440 is a newly identified intronic CA repeat polymorphism located downstream of the 5’-splicing site of exon 5 of estrogen receptor alpha gene (ESR1). Methods: To evaluate the role of D6S440 in bone mineral density (BMD) determination and osteoporosis outcomes prediction, 281 pairs of premenopausal and 395 pairs of postmenopausal Chinese female case-control subjects were studied. The functional significance of D6S440 in determining estrogen receptor (ER ) gene expression was examined in human bone. Results: Post- but not premenopausal women with less CA repeats had lower BMD at both spine and hip. A linear relationship was seen between the number of CA repeats and hip BMD in postmenopausal women (;=0.008; p=0.004). Postmenopausal women with less than 18 CA repeats had higher risks of osteoporosis at the spine (odds ratio (OR) 2.46, 95% confidence interval (CI) 1.30–4.65; p=0.0006) and hip (OR 3.79(1.64–8.74), p=0.0002), and also increased risk of spine and hip fractures (OR 2.31(1.29–4.14), p=0.005). Perimenopausal women with CA repeat size <18 had significantly greater bone loss at the hip (-1.96%) than those with CA repeat size R18 (-1.61%; p=0.029) during 18 months of observation. Subjects with fewer CA repeats had reduced ER mRNA expression in their bone cells. Conclusions: ESR1 CA repeat polymorphism is associated with multiple osteoporosis outcomes and mRNA expression in bone, and this may be a useful genetic marker for fracture risk assessment.-
dc.languageengen_HK
dc.publisherSpringer-Verlag-
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.titleESR1 CA(n) repeat polymorphism is associated with increased risk of osteoporotic fractures and estrogen receptor alpha: mrna expression in boneen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00198-006-0095-0-
dc.identifier.hkuros118519en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats