File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Natural acquisition of Helicobacter pylori in adultdyspeptic patients with or without previousinfection—a 7-year follow-up study

TitleNatural acquisition of Helicobacter pylori in adultdyspeptic patients with or without previousinfection—a 7-year follow-up study
Authors
Issue Date2005
PublisherBlackwell Publishing Asia.
Citation
Australian Gastroenterology Week 2005, Brisbane, Australia, 19-22 October 2005. In Journal of Gastroenterology and Hepatology, 2005, v. 20 n. S1, p. A112 Abstract no. 217 How to Cite?
AbstractBackground and Aim Epidemiological studies have suggestedthat H. pylori infection is acquired mainly in childhood, but rarely inadults. The aim of this study was to prospectively determine the inci-dence of exposure to Helicobacter pylori and subsequent successful col-onization in adults.Methods A total of 252 dyspeptic patients, 147 with successful H.pylori eradication therapy and 105 without previous H. pylori infec-tion, were scheduled for visits at 3, 6, 12, 18, 24, 30, 36, 48, 60, 72and 84 months. A validated 13C-urea urea breath test and a validatedIgG serological test were used to detect H. pylori status at each visit.Clinical, demographic and socio-economic factors were collected atthe entry of the study.Results Overall, 227 patients were followed up for at least 3months. Of these patients, 30 (13.2%) were exposed to H. pyloriduring the follow-up; 20 with previous H. pylori infection and 10without, giving an annual incidence of 3.2% and 2.6%, respectively.The high crude incidence of exposure to H. pylori was associated witha fewer number of bedrooms at home (OR = 0.38, 95% CI:0.18–0.84, c2= 5.98, P = 0.014), and multivariate analysis alsoshowed that number of bedrooms was the independent risk factor forthe exposure to H. pylori (OR = 0.33, 95% CI: 0.12–0.91, c2= 4.61,P = 0.033). H. pylori successfully colonized in the stomachs of 11patients; 10 with previous H. pylori infection and one without, givingan annual rate of 1.6% and 0.3%, respectively. Kaplan-Meier analy-sis revealed that previous H. pylori infection was associated with sub-sequent successful H. pylori colonization (Log Rank Test, P = 0.042).Conclusion There is a constant exposure to H. pylori in adults,regardless of previous infection. However, the incidence of successfulH. pylori colonization is significantly higher in patients with previousH. pylori infection than in those without the infection.
Persistent Identifierhttp://hdl.handle.net/10722/101745
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorWong, RWMen_HK
dc.contributor.authorChan, OOen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorCheung, KLen_HK
dc.contributor.authorFung, FMYen_HK
dc.contributor.authorWong, KWen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T20:02:12Z-
dc.date.available2010-09-25T20:02:12Z-
dc.date.issued2005en_HK
dc.identifier.citationAustralian Gastroenterology Week 2005, Brisbane, Australia, 19-22 October 2005. In Journal of Gastroenterology and Hepatology, 2005, v. 20 n. S1, p. A112 Abstract no. 217en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101745-
dc.description.abstractBackground and Aim Epidemiological studies have suggestedthat H. pylori infection is acquired mainly in childhood, but rarely inadults. The aim of this study was to prospectively determine the inci-dence of exposure to Helicobacter pylori and subsequent successful col-onization in adults.Methods A total of 252 dyspeptic patients, 147 with successful H.pylori eradication therapy and 105 without previous H. pylori infec-tion, were scheduled for visits at 3, 6, 12, 18, 24, 30, 36, 48, 60, 72and 84 months. A validated 13C-urea urea breath test and a validatedIgG serological test were used to detect H. pylori status at each visit.Clinical, demographic and socio-economic factors were collected atthe entry of the study.Results Overall, 227 patients were followed up for at least 3months. Of these patients, 30 (13.2%) were exposed to H. pyloriduring the follow-up; 20 with previous H. pylori infection and 10without, giving an annual incidence of 3.2% and 2.6%, respectively.The high crude incidence of exposure to H. pylori was associated witha fewer number of bedrooms at home (OR = 0.38, 95% CI:0.18–0.84, c2= 5.98, P = 0.014), and multivariate analysis alsoshowed that number of bedrooms was the independent risk factor forthe exposure to H. pylori (OR = 0.33, 95% CI: 0.12–0.91, c2= 4.61,P = 0.033). H. pylori successfully colonized in the stomachs of 11patients; 10 with previous H. pylori infection and one without, givingan annual rate of 1.6% and 0.3%, respectively. Kaplan-Meier analy-sis revealed that previous H. pylori infection was associated with sub-sequent successful H. pylori colonization (Log Rank Test, P = 0.042).Conclusion There is a constant exposure to H. pylori in adults,regardless of previous infection. However, the incidence of successfulH. pylori colonization is significantly higher in patients with previousH. pylori infection than in those without the infection.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia.en_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.titleNatural acquisition of Helicobacter pylori in adultdyspeptic patients with or without previousinfection—a 7-year follow-up studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=20&spage=Supp A112&epage=&date=2005&atitle=Natural+acquisition+of+Helicobacter+pylori+in+adult+dyspeptic+patients+with+or+without+previous+infection+–+a+7-year+follow-up+study. Australian+Gastroenterology+Week+2005,+19+October+2005,+Australia.en_HK
dc.identifier.emailXia, HHX: xiaharry@hotmail.comen_HK
dc.identifier.emailWong, RWM: wmwongg@hku.hken_HK
dc.identifier.emailChan, OO: aoochan@hku.hken_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailLai, KC: kclai@HKUCC.hku.hken_HK
dc.identifier.emailChan, CK: ckchanj@HKUCC-COM.hku.hken_HK
dc.identifier.emailFung, FMY: fionafung20@hotmail.comen_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi1111/j.1440-1746.2005.04091_9.x-
dc.identifier.hkuros117565en_HK
dc.identifier.volume20en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats