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Conference Paper: Patients with coronary artery disease are at high risk for developing colorectal cancer and adenoma: an interim analysis of a prospective study

TitlePatients with coronary artery disease are at high risk for developing colorectal cancer and adenoma: an interim analysis of a prospective study
Authors
Issue Date2006
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
The 2006 Digestive Disease Week - Annual Meeting of the American Gastroenterological Association (AGA 2006) Institute, Los Angeles, CA., 24-25 May 2006. In Gastroenterology, 2006, v. 130 n. 4 suppl. 2, p. A-36-A-37, abstract no. 208 How to Cite?
AbstractBACKGROUND: Identifying high risks groups for developing colorectal neoplasia (cancer and adenoma) (CN) allows early detection and hence prevention. We observed in our retrospective study that there was a strong association between patients with CN and coronary artery disease (CAD), probably due to common risk factors. Aim: To investigate the prevalence of CN in patients with and without CAD in those aged ≥ 50 years in a prospective study and to identify the underlying risk factors. METHODS: Patients were recruited for screening colonoscopy after undergoing coronary angiogram, and was defined as CAD+ if there was greater than 50% stenosis of one of the main arteries, and CAD- if not. Advanced colonic lesion was defined as the presence of cancer, or adenomas with villous component, or with moderate to severe dysplasia, or ≥1cm, or >2 adenomas. Underlying risk factors were recorded. The calculated sample size was 200 in each arm. An interim analysis was carried out at a sample size of 150 at each arm. Pearson chi-square test was carried out to test for the association between CN and CAD. To adjust for the factors of age, sex and other risk factors, a random-effects bivariate logistic regression analysis was used. Bayesian analysis was carried out using the software WinBUGS. Intra-cluster correlation (ICC) is a side product of the model that gives an idea of the strength of the association after adjusting for the explanatory variables. RESULTS: There were 307 patients (68.7% male) recruited, 46.3% of them were CAD+. The prevalence of CN was 30.3% vs 19.4% (p=0.027), and advanced lesions was (16.9% vs 6.7%, P=0.005) in patients with and without CAD. There were 5 colorectal cancers (3.5%) detected in the CAD+ arm but none in CAD- (p=0.015). All the cancers were asymptomatic except anemia was found incidentally in one patient. Using logistic regression analysis, the variance of the random effects σ2 =1.7 (95% CI: 0.42, 4.59), and ICC = 0.32 (95% CI: 0.11, 0.58), both indicates a strong association between CN and CAD after adjusting for the risk factors. Male sex and smoking were risk factors for predicting the occurrence of the two diseases. Conclusion: Patients with CAD+ are at high risk for developing colorectal cancer and adenomas, screening by colonoscopy for these patients is mandatory.
Persistent Identifierhttp://hdl.handle.net/10722/101737
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorJim, MHen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorSiu, DCWen_HK
dc.contributor.authorTong, SMen_HK
dc.contributor.authorNg, FHen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorHu, WHCen_HK
dc.contributor.authorYuen, RMFen_HK
dc.contributor.authorLau, YKen_HK
dc.contributor.authorLee, SWLen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T20:01:48Z-
dc.date.available2010-09-25T20:01:48Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 2006 Digestive Disease Week - Annual Meeting of the American Gastroenterological Association (AGA 2006) Institute, Los Angeles, CA., 24-25 May 2006. In Gastroenterology, 2006, v. 130 n. 4 suppl. 2, p. A-36-A-37, abstract no. 208en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101737-
dc.description.abstractBACKGROUND: Identifying high risks groups for developing colorectal neoplasia (cancer and adenoma) (CN) allows early detection and hence prevention. We observed in our retrospective study that there was a strong association between patients with CN and coronary artery disease (CAD), probably due to common risk factors. Aim: To investigate the prevalence of CN in patients with and without CAD in those aged ≥ 50 years in a prospective study and to identify the underlying risk factors. METHODS: Patients were recruited for screening colonoscopy after undergoing coronary angiogram, and was defined as CAD+ if there was greater than 50% stenosis of one of the main arteries, and CAD- if not. Advanced colonic lesion was defined as the presence of cancer, or adenomas with villous component, or with moderate to severe dysplasia, or ≥1cm, or >2 adenomas. Underlying risk factors were recorded. The calculated sample size was 200 in each arm. An interim analysis was carried out at a sample size of 150 at each arm. Pearson chi-square test was carried out to test for the association between CN and CAD. To adjust for the factors of age, sex and other risk factors, a random-effects bivariate logistic regression analysis was used. Bayesian analysis was carried out using the software WinBUGS. Intra-cluster correlation (ICC) is a side product of the model that gives an idea of the strength of the association after adjusting for the explanatory variables. RESULTS: There were 307 patients (68.7% male) recruited, 46.3% of them were CAD+. The prevalence of CN was 30.3% vs 19.4% (p=0.027), and advanced lesions was (16.9% vs 6.7%, P=0.005) in patients with and without CAD. There were 5 colorectal cancers (3.5%) detected in the CAD+ arm but none in CAD- (p=0.015). All the cancers were asymptomatic except anemia was found incidentally in one patient. Using logistic regression analysis, the variance of the random effects σ2 =1.7 (95% CI: 0.42, 4.59), and ICC = 0.32 (95% CI: 0.11, 0.58), both indicates a strong association between CN and CAD after adjusting for the risk factors. Male sex and smoking were risk factors for predicting the occurrence of the two diseases. Conclusion: Patients with CAD+ are at high risk for developing colorectal cancer and adenomas, screening by colonoscopy for these patients is mandatory.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titlePatients with coronary artery disease are at high risk for developing colorectal cancer and adenoma: an interim analysis of a prospective studyen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=130 &issue=4 Supp 2&spage=A&epage=36&date=2006&atitle=Patients+with+Coronary+Artery+Disease+are+at+High+Risk+for+Developing+Colorectal+Cancer+and+Adenoma:+An+Interim+Analysis+of+a+Prospective+Studyen_HK
dc.identifier.emailChan, OO: aoochan@hku.hken_HK
dc.identifier.emailLam, KF: hrntlkf@hkucc.hku.hken_HK
dc.identifier.emailTong, SM: tongsma@HKUCC.hku.hken_HK
dc.identifier.emailNg, FH: ngfhong@HKUCC.hku.hken_HK
dc.identifier.emailHui, WM: hrmehwm@hkucc.hku.hken_HK
dc.identifier.emailChan, CK: ckchanj@HKUCC-COM.hku.hken_HK
dc.identifier.emailLai, KC: kclai@HKUCC.hku.hken_HK
dc.identifier.emailHu, HC: hchu@HKUCC.hku.hken_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLau, YK: yklau@ha.org.hken_HK
dc.identifier.emailLee, SWL: drsl@HKUCC.hku.hken_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityLam, KF=rp00718en_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.doi10.1016/S0016-5085(06)60008-5-
dc.identifier.hkuros116858en_HK
dc.identifier.volume130en_HK
dc.identifier.issue4 suppl. 2en_HK
dc.identifier.spageA-36, abstract no. 208-
dc.identifier.epageA-37en_HK

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