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Conference Paper: Aspirin does not prevent recurrence of colorrectal adenomas in patients with coronary artery disease

TitleAspirin does not prevent recurrence of colorrectal adenomas in patients with coronary artery disease
Authors
Issue Date2007
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Digestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute, Washington, DC, 19-24 May 2007. In Gastroenterology, 2007, v. 132 n. 4, p. A-194 Abstract no. S1201 How to Cite?
AbstractBackground: Aspirin has been reported to prevent colorectal adenoma recurrence. In contrast, we observed a high prevalence of colorectal adenomas in patients with coronary artery disease (CAD) in our previous study. Aims: To investigate whether aspirin prevents colorectal adenomas recurrence in patients with CAD. Methods: Patients scheduled for coronary angiography as workup for CAD were enrolled for screening colonoscopy as described in our previous study. Patients with colorectal adenoma after a clearance colonoscopy were recruited for follow up study. Surveillance colonoscopy was performed at the end of first year. Aspirin was prescribed to patients with CAD (aspirin group) as part of the routine management, but not to those without (control group). Results: There were 46 patients with coronary artery disease (aspirin group) and 51 without (control). There was no difference in sex (91.3% male vs 82.4%, p=0.19), age (66 ± 7 vs 64 ± 8 yrs, p=0.18) or advanced colorectal lesion (23.9% vs 17.6%, p=0.44) at screening colonoscopy in the two groups. In the surveillance colonoscopy, the aspirin group, did not have a lower colorectal adenoma recurrence rate (32.6% vs 27.5%, p=0.58) nor advanced lesion (15.2% vs 7.8%, p=0.25) than the control. However, the presence of advanced lesion in the first screening colonoscopy predicted the subsequent recurrence of colorectal adenoma (50% vs 24.7%, p=0.028). Conclusion: Aspirin does not reduce colorectal adenoma recurrence rate at 1-year in those with CAD. This may be secondary to the multiple concomitant risk factors.
Persistent Identifierhttp://hdl.handle.net/10722/101625
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorJim, MHen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorSiu, DCWen_HK
dc.contributor.authorTong, SMen_HK
dc.contributor.authorNg, FHen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T19:57:15Z-
dc.date.available2010-09-25T19:57:15Z-
dc.date.issued2007en_HK
dc.identifier.citationDigestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute, Washington, DC, 19-24 May 2007. In Gastroenterology, 2007, v. 132 n. 4, p. A-194 Abstract no. S1201en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101625-
dc.description.abstractBackground: Aspirin has been reported to prevent colorectal adenoma recurrence. In contrast, we observed a high prevalence of colorectal adenomas in patients with coronary artery disease (CAD) in our previous study. Aims: To investigate whether aspirin prevents colorectal adenomas recurrence in patients with CAD. Methods: Patients scheduled for coronary angiography as workup for CAD were enrolled for screening colonoscopy as described in our previous study. Patients with colorectal adenoma after a clearance colonoscopy were recruited for follow up study. Surveillance colonoscopy was performed at the end of first year. Aspirin was prescribed to patients with CAD (aspirin group) as part of the routine management, but not to those without (control group). Results: There were 46 patients with coronary artery disease (aspirin group) and 51 without (control). There was no difference in sex (91.3% male vs 82.4%, p=0.19), age (66 ± 7 vs 64 ± 8 yrs, p=0.18) or advanced colorectal lesion (23.9% vs 17.6%, p=0.44) at screening colonoscopy in the two groups. In the surveillance colonoscopy, the aspirin group, did not have a lower colorectal adenoma recurrence rate (32.6% vs 27.5%, p=0.58) nor advanced lesion (15.2% vs 7.8%, p=0.25) than the control. However, the presence of advanced lesion in the first screening colonoscopy predicted the subsequent recurrence of colorectal adenoma (50% vs 24.7%, p=0.028). Conclusion: Aspirin does not reduce colorectal adenoma recurrence rate at 1-year in those with CAD. This may be secondary to the multiple concomitant risk factors.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titleAspirin does not prevent recurrence of colorrectal adenomas in patients with coronary artery diseaseen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=132&issue=4&spage=A194&epage=&date=2007&atitle=Aspirin+does+not+prevent+recurrence+of+colorrectal+adenomas+in+patients+with+coronary+artery+disease.++Digestive+Disease+Week+2007,+Washington+DC,+USA,+19-24+Mayen_HK
dc.identifier.emailChan, AOO: aoochan@hku.hken_HK
dc.identifier.emailTong, SM: tongsma@HKUCC.hku.hken_HK
dc.identifier.emailNg, FH: ngfhong@HKUCC.hku.hken_HK
dc.identifier.emailWong, SY: maggie10_18@yahoo.comen_HK
dc.identifier.emailHui, WM: hrmehwm@hkucc.hku.hken_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0016-5085(07)60009-2-
dc.identifier.hkuros131420en_HK
dc.identifier.volume132en_HK
dc.identifier.issue4en_HK
dc.identifier.spage194en_HK

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