A pilot study using Titan in the treatment of facial wrinkles in Asians.

Abstract

BACKGROUND AND OBJECTIVE: We report for the first time the use of a new laser technology, Titan (Cutera, Brisbane, CA) in the treatment of facial wrinkles in Asians. This device is a non-coherently selectively filtered infrared device operating in the 1100 to 1800 nm band intended to provide dermal heating to cause immediate collagen contraction and stimulate subsequent collagen remodeling. The epidermis is preserved through continuous cooling. DESIGN/MATERIAL AND METHODS: Twenty Chinese female patients with skin types III–V were recruited in this study. Patients received two treatments on one side of the face administered at 4-week intervals. Treatments were performed with the Titan handpiece of spot size of 1.0 x 1.5 cm, with three passes of fluence 32–48 J/cm2. Assessment of changes in wrinkles, pore size and dyspigmentation were assessed serially by direct clinical evaluation, standardized pictures and patient questionnaires at baseline, and at one and three months after the second treatment. RESULTS: After the second treatment, 48% and 60% of the subjects reported moderate to significant improvement in wrinkles at 1 month and 3 months respectively. Blinded observers’ assessments were less remarkable, with most subjects showing mild to moderate improvement in wrinkles; findings for pore size were inconclusive. The procedure was well tolerated by all patients. No post-inflammatory hyperpigmentation (PIH), swelling or scarring occurred. CONCLUSION: Titan gives a mild to moderate improvement in the treatment of facial wrinkles in Asians with few adverse effects.