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Conference Paper: Arterial stiffness and advanced glycation end products in type 2 diabetes mellitus

TitleArterial stiffness and advanced glycation end products in type 2 diabetes mellitus
Authors
Issue Date2006
PublisherBlackwell Science
Citation
The 19th World Diabetes Congress, Cape Town, South Africa, 3-7 December 2006. In Diabetic Medicine, 2006, v. 23 n. S4, p. 673 Abstract no. P1919 How to Cite?
AbstractAim: Binding of advanced glycation end products (AGEs) to theircellular receptors plays an important role in the development ofdiabetic vascular complications and animal studies have shown that thesoluble receptor for advanced glycation end products (sRAGE) may havecytoprotective properties by acting as a decoy. An inverse associationbetween endogenous sRAGE level and carotid intima-media thicknesshas recently been reported in type 1 diabetic patients. We haveinvestigated whether there is an association between arterial stiffnessand serum levels of AGEs and sRAGE in patients with type 2 diabetesmellitus.Methods: Arterial stiffness was assessed non-invasively by measuringcarotid-femoral pulse wave velocity (PWV). Serum sRAGE was assayed byan ELISA kit (R&D Systems) and serum AGEs by competitive ELISA using apolyclonal rabbit antisera raised against AGE-RNase.Results: PWV was significantly increased in type 2 diabetic patients(n = 137) compared with healthy age-matched controls (n = 67)(9.3 ± 2.2 m/s vs. 7.3 ± 1.2 respectively, P<0.01). In the diabeticpatients, PWV correlated with age (r = 0.50, P<0.01), body mass index(r = 0.21, P = 0.01), HDL (r = -0.18, P = 0.03), systolic BP (r = 0.54,P<0.01), serum AGEs (r = 0.33, P<0.01) but not with sRAGE. Todetermine what were the determinants of PWV, stepwise linearregression analysis was performed. Gender, smoking status, duration ofdiabetes and continuous variables which showed an association withPWV on univariate analysis were entered into the model. Systolic BP, age,serum AGEs, body mass index and duration of diabetes were found to beindependent determinants of PWV.Conclusion: Arterial stiffness is increased in type 2 diabetic patients andis associated with serum AGEs but not sRAGE. The association betweenserum AGEs and arterial stiffness is independent of the classicalcardiovascular risk factors.
Persistent Identifierhttp://hdl.handle.net/10722/101332
ISSN
2015 Impact Factor: 3.152
2015 SCImago Journal Rankings: 1.654

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorChow, WSen_HK
dc.contributor.authorWong, Yen_HK
dc.contributor.authorBucala, Ren_HK
dc.contributor.authorBetteridge, DJen_HK
dc.date.accessioned2010-09-25T19:45:20Z-
dc.date.available2010-09-25T19:45:20Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 19th World Diabetes Congress, Cape Town, South Africa, 3-7 December 2006. In Diabetic Medicine, 2006, v. 23 n. S4, p. 673 Abstract no. P1919-
dc.identifier.issn0742-3071-
dc.identifier.urihttp://hdl.handle.net/10722/101332-
dc.description.abstractAim: Binding of advanced glycation end products (AGEs) to theircellular receptors plays an important role in the development ofdiabetic vascular complications and animal studies have shown that thesoluble receptor for advanced glycation end products (sRAGE) may havecytoprotective properties by acting as a decoy. An inverse associationbetween endogenous sRAGE level and carotid intima-media thicknesshas recently been reported in type 1 diabetic patients. We haveinvestigated whether there is an association between arterial stiffnessand serum levels of AGEs and sRAGE in patients with type 2 diabetesmellitus.Methods: Arterial stiffness was assessed non-invasively by measuringcarotid-femoral pulse wave velocity (PWV). Serum sRAGE was assayed byan ELISA kit (R&D Systems) and serum AGEs by competitive ELISA using apolyclonal rabbit antisera raised against AGE-RNase.Results: PWV was significantly increased in type 2 diabetic patients(n = 137) compared with healthy age-matched controls (n = 67)(9.3 ± 2.2 m/s vs. 7.3 ± 1.2 respectively, P<0.01). In the diabeticpatients, PWV correlated with age (r = 0.50, P<0.01), body mass index(r = 0.21, P = 0.01), HDL (r = -0.18, P = 0.03), systolic BP (r = 0.54,P<0.01), serum AGEs (r = 0.33, P<0.01) but not with sRAGE. Todetermine what were the determinants of PWV, stepwise linearregression analysis was performed. Gender, smoking status, duration ofdiabetes and continuous variables which showed an association withPWV on univariate analysis were entered into the model. Systolic BP, age,serum AGEs, body mass index and duration of diabetes were found to beindependent determinants of PWV.Conclusion: Arterial stiffness is increased in type 2 diabetic patients andis associated with serum AGEs but not sRAGE. The association betweenserum AGEs and arterial stiffness is independent of the classicalcardiovascular risk factors.-
dc.languageengen_HK
dc.publisherBlackwell Science-
dc.relation.ispartofDiabetic Medicineen_HK
dc.titleArterial stiffness and advanced glycation end products in type 2 diabetes mellitusen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTan, KCB: kcbtan@hku.hken_HK
dc.identifier.emailShiu, SWM: swmshiu@HKUSUA.hku.hken_HK
dc.identifier.emailChow, WS: chowws01@HKUCC.hku.hken_HK
dc.identifier.emailWong, Y: ywong@HKUCC-COM.hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1464-5491.2006.02039_11.x-
dc.identifier.hkuros131672en_HK

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