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Conference Paper: Patients with coronary artery disease had high prevalanece of colorectal cancer and adenoma: END-results of metabolic syndrome and smoking

TitlePatients with coronary artery disease had high prevalanece of colorectal cancer and adenoma: END-results of metabolic syndrome and smoking
Authors
Issue Date2007
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Digestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute, Washington, DC, 19-24 May 2007. In Gastroenterology, 2007, v. 132 n. 4, p. A-65 Abstract no. 381 How to Cite?
AbstractBackground: Our previous study showed an association between colorectal neoplasm (CN) and coronary artery disease (CAD), probably due to sharing of common risk factors. Aim: To investigate the prevalence of CN in patients with and without CAD in those aged ≥50 years prospectively and to identify the underlying risk factors. Methods: Patients were recruited for screening colonoscopy after undergoing coronary angiography. They were defined as CAD+ (n=206) if ≥50% diameter stenosis was observed in any one of the major coronary arteries, and CAD- (n=208) if not. A second age and sex matched control group was recruited from the general population (n=207). The prevalence of colonic lesions and underlying risk factors was compared by Pearson chi-square test. A bivariate logistic regression analysis was performed to adjust for age and sex and to identify independent risk factors. Results: The prevalence of the lesions in the CAD+, CAD- and general population group were 40.3%, 28.8%, and 32.9% (p=0.045) for endoscopic polyp, 34.0%, 18.8%, and 20.8% (p<0.0001) for CN, 18.4%, 8.7%, and 5.8% (p<0.00001) for advanced lesion, and 4.4%, 0.5%, and 1.4% (p=0.014) for cancer, respectively. All except one cancers were detected at early stage. After adjusting for age and sex, smoking history (OR: 4.74, CI: 1.38 to 19) and metabolic syndrome (OR: 5.99; CI: 1.43 to 28.0) were independent factors for the coexistence of CAD and advanced lesion. Conclusion: Life style modification is important to prevent the development of both CAD and advanced colonic lesions simultaneously. CAD+ is a surrogate marker for high prevalence of CN, necessitating immediate colonoscopy screening.
Persistent Identifierhttp://hdl.handle.net/10722/101271
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorJim, MHen_HK
dc.contributor.authorLam, KFen_HK
dc.contributor.authorSiu, DCWen_HK
dc.contributor.authorTong, SMen_HK
dc.contributor.authorNg, FHen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorChan, Pen_HK
dc.contributor.authorWong, Gen_HK
dc.contributor.authorYuen, RMFen_HK
dc.contributor.authorLau, YKen_HK
dc.contributor.authorLee, SWLen_HK
dc.contributor.authorSeto, MLen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T19:42:49Z-
dc.date.available2010-09-25T19:42:49Z-
dc.date.issued2007en_HK
dc.identifier.citationDigestive Disease Week and the 108th Annual Meeting of the American Gastroenterological Association Institute, Washington, DC, 19-24 May 2007. In Gastroenterology, 2007, v. 132 n. 4, p. A-65 Abstract no. 381en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101271-
dc.description.abstractBackground: Our previous study showed an association between colorectal neoplasm (CN) and coronary artery disease (CAD), probably due to sharing of common risk factors. Aim: To investigate the prevalence of CN in patients with and without CAD in those aged ≥50 years prospectively and to identify the underlying risk factors. Methods: Patients were recruited for screening colonoscopy after undergoing coronary angiography. They were defined as CAD+ (n=206) if ≥50% diameter stenosis was observed in any one of the major coronary arteries, and CAD- (n=208) if not. A second age and sex matched control group was recruited from the general population (n=207). The prevalence of colonic lesions and underlying risk factors was compared by Pearson chi-square test. A bivariate logistic regression analysis was performed to adjust for age and sex and to identify independent risk factors. Results: The prevalence of the lesions in the CAD+, CAD- and general population group were 40.3%, 28.8%, and 32.9% (p=0.045) for endoscopic polyp, 34.0%, 18.8%, and 20.8% (p<0.0001) for CN, 18.4%, 8.7%, and 5.8% (p<0.00001) for advanced lesion, and 4.4%, 0.5%, and 1.4% (p=0.014) for cancer, respectively. All except one cancers were detected at early stage. After adjusting for age and sex, smoking history (OR: 4.74, CI: 1.38 to 19) and metabolic syndrome (OR: 5.99; CI: 1.43 to 28.0) were independent factors for the coexistence of CAD and advanced lesion. Conclusion: Life style modification is important to prevent the development of both CAD and advanced colonic lesions simultaneously. CAD+ is a surrogate marker for high prevalence of CN, necessitating immediate colonoscopy screening.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titlePatients with coronary artery disease had high prevalanece of colorectal cancer and adenoma: END-results of metabolic syndrome and smokingen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=132&issue=4&spage=A65&epage=&date=2007&atitle=Patients+with+coronary+artery+disease+had+high+prevalanece+of+colorectal+cancer+and+adenoma:+END-results+of+metabolic+syndrome+and+smoking.++Digestive+Disease+Week+2007,+Washington+DEc,+USA,+19-24+Mayen_HK
dc.identifier.emailChan, AOO: aoochan@hku.hken_HK
dc.identifier.emailTong, SM: tongsma@HKUCC.hku.hken_HK
dc.identifier.emailNg, FH: ngfhong@HKUCC.hku.hken_HK
dc.identifier.emailWong, SY: maggie10_18@yahoo.comen_HK
dc.identifier.emailHui, WM: hrmehwm@hkucc.hku.hken_HK
dc.identifier.emailChan, CK: ckchanj@HKUCC-COM.hku.hken_HK
dc.identifier.emailLai, KC: kclai@HKUCC.hku.hken_HK
dc.identifier.emailCheung, TK: cheungtingkin@yahoo.comen_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailLau, YK: yklau@ha.org.hken_HK
dc.identifier.emailLee, SWL: drsl@HKUCC.hku.hken_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0016-5085(07)60009-2-
dc.identifier.hkuros131414en_HK
dc.identifier.volume132en_HK
dc.identifier.issue4en_HK
dc.identifier.spage65en_HK

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