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Conference Paper: Manganese superoxide dismutase and catalase geneticpolymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong

TitleManganese superoxide dismutase and catalase geneticpolymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
Citation
The IASLC 11th World Conference on Lung Cancer (WCLC 2005), Barcelona, Spain, 3-6 July 2005. In Lung Cancer, 2005 v. 49 suppl. 2, p. S191, abstract no. P290 How to Cite?
AbstractBACKGROUND: Antioxidants play an important role in counteracting the effects of potential carcinogens We aim to investigate the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms, and their association with erythrocyte antioxidants activities. METHODS: This is a prospective case-control study involving patients with confirmed lung cancer and healthy controls Genotyping of MnSOD and catalase in DNA extracted from peripheral white cells was performed by polymerase chain reaction based restriction fragment length polymorphism. Erythrocyte superoxide dismutase and catalase activities were measured spectrophotometrically using chemical kinetic reactions. RESULTS: We recruited 340 patients with lung cancer (67% males. 58.3±11.0 years. 55% adenocarcinoma) and 289 healthy controls. The allelic frequencies of the variant in MnSOD (Val allele) and catalase (C allele) genes are common (>85%). with similar distribution, in both lung cancer patients and controls. The homozygous variant genotypes of MnSOD and catalase were not associated with increased lung cancer risk. The erythrocyte SOD activity was significantly lower in lung cancer patients compared to controls (27±33 versus 82±30 U/g haemoglobin: p < 0 001). irrespective of different genotypes. However catalase activity was not different between patients and controls (0.036±0.061 versus 0.032±0.025U/g haemoglobin), though it was lower among those with CC genotype compared with TC and TT genotypes in lung cancer patients. CONCLUSIONS: The common Ala16Val MnSOD polymorphism and C T substitution in the promoter region of the catalase gone confer no increased risk of lung cancer of Chinese in Hong Kong.
DescriptionThis journal suppl. entitled: Taxotere as a Cornerstone Treatment of NSCLC - Proceedings from Two Satellite Symposia IASLC 11th World Conference on Lung Cancer
Persistent Identifierhttp://hdl.handle.net/10722/101257
ISSN
2015 Impact Factor: 3.767
2015 SCImago Journal Rankings: 1.923

 

DC FieldValueLanguage
dc.contributor.authorHo, JCMen_HK
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorHo, Sen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorChan, MMWen_HK
dc.date.accessioned2010-09-25T19:42:15Z-
dc.date.available2010-09-25T19:42:15Z-
dc.date.issued2005en_HK
dc.identifier.citationThe IASLC 11th World Conference on Lung Cancer (WCLC 2005), Barcelona, Spain, 3-6 July 2005. In Lung Cancer, 2005 v. 49 suppl. 2, p. S191, abstract no. P290en_HK
dc.identifier.issn0169-5002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101257-
dc.descriptionThis journal suppl. entitled: Taxotere as a Cornerstone Treatment of NSCLC - Proceedings from Two Satellite Symposia IASLC 11th World Conference on Lung Cancer-
dc.description.abstractBACKGROUND: Antioxidants play an important role in counteracting the effects of potential carcinogens We aim to investigate the risk of lung cancer development with respect to manganese superoxide dismutase (MnSOD) and catalase genetic polymorphisms, and their association with erythrocyte antioxidants activities. METHODS: This is a prospective case-control study involving patients with confirmed lung cancer and healthy controls Genotyping of MnSOD and catalase in DNA extracted from peripheral white cells was performed by polymerase chain reaction based restriction fragment length polymorphism. Erythrocyte superoxide dismutase and catalase activities were measured spectrophotometrically using chemical kinetic reactions. RESULTS: We recruited 340 patients with lung cancer (67% males. 58.3±11.0 years. 55% adenocarcinoma) and 289 healthy controls. The allelic frequencies of the variant in MnSOD (Val allele) and catalase (C allele) genes are common (>85%). with similar distribution, in both lung cancer patients and controls. The homozygous variant genotypes of MnSOD and catalase were not associated with increased lung cancer risk. The erythrocyte SOD activity was significantly lower in lung cancer patients compared to controls (27±33 versus 82±30 U/g haemoglobin: p < 0 001). irrespective of different genotypes. However catalase activity was not different between patients and controls (0.036±0.061 versus 0.032±0.025U/g haemoglobin), though it was lower among those with CC genotype compared with TC and TT genotypes in lung cancer patients. CONCLUSIONS: The common Ala16Val MnSOD polymorphism and C T substitution in the promoter region of the catalase gone confer no increased risk of lung cancer of Chinese in Hong Kong.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcanen_HK
dc.relation.ispartofLung Canceren_HK
dc.rightsLung Cancer. Copyright © Elsevier Ireland Ltd.en_HK
dc.titleManganese superoxide dismutase and catalase geneticpolymorphisms, activity levels and lung cancer risk in Chinese in Hong Kongen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0169-5002&volume=49&issue=Suppl 2&spage=S191&epage=&date=2005&atitle=Manganese+superoxide+dismutase+and+catalase+genetic+polymorphisms,+activity+levels+and+lung+cancer+risk+in+Chinese+in+Hong+Kong.+11th+World+Conference+on+Lung+Cancer+en_HK
dc.identifier.emailHo, JCM: jhocm@hku.hken_HK
dc.identifier.emailMak, JCW: judymak@HKUCC.hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.emailTsang, KWT: kwttsang@hku.hken_HK
dc.identifier.emailLam, WK: lamwk@hku.hken_HK
dc.identifier.emailChan, MMW: mmwchan@hku.hken_HK
dc.identifier.authorityHo, JCM=rp00258en_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0169-5002(05)80784-6-
dc.identifier.hkuros117982en_HK
dc.identifier.volume49en_HK
dc.identifier.issuesuppl. 2en_HK
dc.identifier.spageS191, abstract no. P290-
dc.identifier.epageS191, abstract no. P290-

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