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Conference Paper: The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer

TitleThe association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer
Authors
Issue Date2005
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
The 2005 Digestive Disease Week (DDW), Chicago, IL., 14-19 May 2005. In Gastroenterology, 2005, v. 128 n. 4 S2, p. A-399-A-400 How to Cite?
AbstractBackground: The importance of interleukin 1beta polymorphism (IL-1) has been demonstrated in gastric cancer through the production of hypochlorhydria and atrophic gastritis. Hypermethylation at tumor suppressor gene is an important mechanism in gastric carcinogenesis. Aim: to examine if association exists between IL-1 polymorphism and hypermethylation. Methods: We determined IL-1B-511/-31 and IL-1RN genotypes in 41 patients with gastric cancer. Hypermethylation at MGMT and p16 were assessed in these patients using Methylation Specific PCR and confirmed by sequencing. Results: Within the IL-1B gene, the T and C alleles at the -511 locus were in near total linkage disequilibrium with the C and T alleles at the -31 locus. The allele frequencies at IL-1B-511 was 8/41 (19.5%), 28/41 (68.3%), and 5/41 (12.2%) for T/T, C/T, and C/C genotypes, respectively. Allele 2 of the IL-1RN locus was not detected in any patients. Frequency of hypermethylation at MGMT and p16 was 31.7% (13/41) and 29.3% (12/41), respectively. The presence of hypermethylation at any locus was observed in 6/8 (75%) patients with the proinflammatory IL-1B-511 T/T genotype, in comparison to 1/5 (20%) of the patients with IL-1B-511 C/C genotype (p 0.04), and in 16/28 (57%) of the patients with IL-1B-511 T/C genotype. Conclusion: Proinflammatory IL-1 polymorphisms are associated with hypermethylation at tumor suppressor genes in gastric cancer, which may be the result of hypochlorhydria and atrophic gastritis.
Persistent Identifierhttp://hdl.handle.net/10722/101176
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorChan, OOen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorSun, YWen_HK
dc.contributor.authorCheung, HKLen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorYuen, RMFen_HK
dc.contributor.authorHui, WMen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T19:38:59Z-
dc.date.available2010-09-25T19:38:59Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 2005 Digestive Disease Week (DDW), Chicago, IL., 14-19 May 2005. In Gastroenterology, 2005, v. 128 n. 4 S2, p. A-399-A-400en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101176-
dc.description.abstractBackground: The importance of interleukin 1beta polymorphism (IL-1) has been demonstrated in gastric cancer through the production of hypochlorhydria and atrophic gastritis. Hypermethylation at tumor suppressor gene is an important mechanism in gastric carcinogenesis. Aim: to examine if association exists between IL-1 polymorphism and hypermethylation. Methods: We determined IL-1B-511/-31 and IL-1RN genotypes in 41 patients with gastric cancer. Hypermethylation at MGMT and p16 were assessed in these patients using Methylation Specific PCR and confirmed by sequencing. Results: Within the IL-1B gene, the T and C alleles at the -511 locus were in near total linkage disequilibrium with the C and T alleles at the -31 locus. The allele frequencies at IL-1B-511 was 8/41 (19.5%), 28/41 (68.3%), and 5/41 (12.2%) for T/T, C/T, and C/C genotypes, respectively. Allele 2 of the IL-1RN locus was not detected in any patients. Frequency of hypermethylation at MGMT and p16 was 31.7% (13/41) and 29.3% (12/41), respectively. The presence of hypermethylation at any locus was observed in 6/8 (75%) patients with the proinflammatory IL-1B-511 T/T genotype, in comparison to 1/5 (20%) of the patients with IL-1B-511 C/C genotype (p 0.04), and in 16/28 (57%) of the patients with IL-1B-511 T/C genotype. Conclusion: Proinflammatory IL-1 polymorphisms are associated with hypermethylation at tumor suppressor genes in gastric cancer, which may be the result of hypochlorhydria and atrophic gastritis.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titleThe association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric canceren_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=128 &issue=Suppl 2&spage=1399&epage=400&date=2005&atitle=The+association+between+interleukin+1+beta+polymorphism+and+hypermethylation+at+tumor+suppressor+genes+in+gastric+cancer.+en_HK
dc.identifier.emailChan, OO: aoochan@hku.hken_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailHui, WM: hrmehwm@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityYuen, RMF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/j.gastro.2005.04.003-
dc.identifier.hkuros122656en_HK
dc.identifier.hkuros99435-
dc.identifier.hkuros130908-
dc.identifier.volume128en_HK
dc.identifier.issue4 suppl. 2en_HK
dc.identifier.spageA-399en_HK
dc.identifier.epageA-400en_HK

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