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Conference Paper: Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong

TitleTrends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong
Authors
Issue Date2005
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
Citation
Digestive Disease Week, Chicago, IL, 14-19 May 2005. In Gastroenterology, 2005, v. 128 n. 4 S2, p. A230 How to Cite?
AbstractBackground and aim: Peptic ulcer disease is common in the world, and is strongly associated with Helicobacter pylori infection, and use of non-steroidal anti-inflammatory drugs (NSAIDs). The aim of the present study was to investigate the trends of prevalence of peptic ulcer disease and H. pylori infection and frequency of NSAID intake over the past 6 years in Hong Kong. Methods: Clinical and endoscopic data on patients referred by general practitioners including H. pylori status (as determined by a rapid urease test and histology), NSAIDs use during 1998 and 2003 were retrospectively retrieved in Hong Kong University Queen Mary Hospital. Results: A total 2409 cases of patients who had upper gastrointestinal symptoms and undergone endoscopy were included. Overall, 369 cases of peptic ulcer disease (238 duodenal ulcer, 116 gastric ulcer and 15 both duodenal and gastric ulcer) were identified. There were reduced trends from 1998 to 2003 in the prevalence of peptic ulcer disease (chi square for trend 4.043, P0.044) andH. pylori infection (chi square for trend 10.144, P0.0014), but not in the frequency NSAID intake. Classifying two sets of the data from 1998 to 2000 and from 2001 to 2003, the prevalence of peptic ulcer disease and H. pylori infection during 2001 and 2003 was significantly lower than that during 1998 and 2000 (13.52% vs. 16.55%, chi square9.011, OR1.269, 95%CI: 1.014~1.588, P0.042 for peptic ulcer disease and 29.44% vs. 35.25%, chi square4.120, OR1.304, 95%CI: 1.099~1.548, P0.0027). However, NSAID intake remained unchanged (4.72% vs 3.14%). In addition, both H. pylori infection and NSAID intake were associated with peptic ulcer disease. However, there was no association between H. pylori infection and NSAID intake. Conclusion: There is a decreased trend in the prevalence of peptic ulcer disease from 1998 to 2003 in Hong Kong, which is likely to be associated with the reduced prevalence of H. pylori infection.
Persistent Identifierhttp://hdl.handle.net/10722/101086
ISSN
2015 Impact Factor: 18.187
2015 SCImago Journal Rankings: 7.170

 

DC FieldValueLanguage
dc.contributor.authorXia, Ben_HK
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorChan, OOen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorHu, HCen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2010-09-25T19:35:24Z-
dc.date.available2010-09-25T19:35:24Z-
dc.date.issued2005en_HK
dc.identifier.citationDigestive Disease Week, Chicago, IL, 14-19 May 2005. In Gastroenterology, 2005, v. 128 n. 4 S2, p. A230en_HK
dc.identifier.issn0016-5085en_HK
dc.identifier.urihttp://hdl.handle.net/10722/101086-
dc.description.abstractBackground and aim: Peptic ulcer disease is common in the world, and is strongly associated with Helicobacter pylori infection, and use of non-steroidal anti-inflammatory drugs (NSAIDs). The aim of the present study was to investigate the trends of prevalence of peptic ulcer disease and H. pylori infection and frequency of NSAID intake over the past 6 years in Hong Kong. Methods: Clinical and endoscopic data on patients referred by general practitioners including H. pylori status (as determined by a rapid urease test and histology), NSAIDs use during 1998 and 2003 were retrospectively retrieved in Hong Kong University Queen Mary Hospital. Results: A total 2409 cases of patients who had upper gastrointestinal symptoms and undergone endoscopy were included. Overall, 369 cases of peptic ulcer disease (238 duodenal ulcer, 116 gastric ulcer and 15 both duodenal and gastric ulcer) were identified. There were reduced trends from 1998 to 2003 in the prevalence of peptic ulcer disease (chi square for trend 4.043, P0.044) andH. pylori infection (chi square for trend 10.144, P0.0014), but not in the frequency NSAID intake. Classifying two sets of the data from 1998 to 2000 and from 2001 to 2003, the prevalence of peptic ulcer disease and H. pylori infection during 2001 and 2003 was significantly lower than that during 1998 and 2000 (13.52% vs. 16.55%, chi square9.011, OR1.269, 95%CI: 1.014~1.588, P0.042 for peptic ulcer disease and 29.44% vs. 35.25%, chi square4.120, OR1.304, 95%CI: 1.099~1.548, P0.0027). However, NSAID intake remained unchanged (4.72% vs 3.14%). In addition, both H. pylori infection and NSAID intake were associated with peptic ulcer disease. However, there was no association between H. pylori infection and NSAID intake. Conclusion: There is a decreased trend in the prevalence of peptic ulcer disease from 1998 to 2003 in Hong Kong, which is likely to be associated with the reduced prevalence of H. pylori infection.-
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastroen_HK
dc.relation.ispartofGastroenterologyen_HK
dc.titleTrends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kongen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0016-5085&volume=128&issue=4 Suppl 2&spage=A230&epage=&date=2005&atitle=Trends+in+prevalence+of+peptic+ulcer+disease+and+Helicobacter+pylori+infection+and+frequency+of+NSAID+intake+in+general+practitioner-referred+dyspeptic+patients+over+6+years+in+Hong+Kongen_HK
dc.identifier.emailXia, HHX: xiaharry@hotmail.comen_HK
dc.identifier.emailLam, SK: deanmed@hku.hken_HK
dc.identifier.emailChan, OO: aoochan@hku.hken_HK
dc.identifier.emailLai, KC: kclai@HKUCC.hku.hken_HK
dc.identifier.emailHu, HC: hchu@HKUCC.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1053/j.gastro.2005.04.003-
dc.identifier.hkuros99452en_HK
dc.identifier.volume128en_HK
dc.identifier.issue4 Suppl 2en_HK
dc.identifier.spage230en_HK

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