File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: A comparison of non-TBI and TBI conditioning regimens in bone marrow recipients undergoing match-unrelated transplantation in Hong Kong

TitleA comparison of non-TBI and TBI conditioning regimens in bone marrow recipients undergoing match-unrelated transplantation in Hong Kong
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt
Citation
The 2000 Tandem BMT Meetings, 26 March-1 April 2000. In Biology of Blood and Marrow Transplantation, 2000, v. 6 n. 2, p. 124, abstract no. 27 How to Cite?
AbstractThe present study investigated the effects of non-Total Body Irradiation (TBI) conditioning on the outcome of 8 patients (CML = 5 ; A M L = 3; Mean age 32.8 ± 3.3) undergoing Matched-Unrelated Bone Marrow Transplantation (MUD BMT) using busulfan (16 mg/kg) and cyclophosphamide (150 mg/kg). The outcome of 28 patients ( C M L = 16; AML = 7; Biphenotypic acute leukaemia = 2; ALL = 2 ; M D S = 1) using TBI (12Gy) containing regimen (Mean age 29.3 ± 1.7 ) were also analyzed. The number of days requiring TPN (due to oral mucositis) was significantly lower in the Bu-Cy group (18 ± 3.6 days) compared with the control (31.9 ± 4.1 days, p<0.05). There were no differences in neutrophil (ANC > 0.5 x 10 9/L) and platelet (>25 x 109/ L without transfusion) engraftments. The Bu-Cy group had less venoocclusive disease (VOD) (2/8 vs 11/28 in control) but more haemorrhagic cystitis (HC) (3/8 vs 5/28 in control) though the differences were not s i g n i ficant (p>0.05). Patients in the Bu-Cy group also had a signific a n t l y lower occurrence (1/8) of severe GVHD (Overall grade ³2) than the control group (18/28) (p<0.05). Transplant-related mortality (TRM) within 100 days after BMT was 0 in the Bu-Cy group but was 7 (out of 28) in the control (GVHD related = 4; Regimen-related toxicity = 2 ; Graft failure = 1). The difference, however, did not reach statistical sign i ficance (p>0.05). There was no difference in the occurrence of early graft failure in both groups of patients (1/8 in the Bu-Cy group vs 3/28 in the control). In conclusion, we have shown that the use of Bu-Cy during conditioning in MUD BMT had no adverse effect on neutrophil and platelet engraftments and did not increase the occurrence of graft failure. TBI based conditioning was associated with increased severity of oral mucositis and increased risk of VOD and severe GVHD and a higher transplant-related mortality.
DescriptionCombined annual meetings of CIBMTR and the American Society of Blood and Marrow Transplantation (ASBMT)
pp. 116-161 of this journal issue entitled: Abstracts from the Annual Tandem Meetings of the American Society for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry ... 2000
Persistent Identifierhttp://hdl.handle.net/10722/100994
ISSN
2015 Impact Factor: 3.98
2015 SCImago Journal Rankings: 2.094

 

DC FieldValueLanguage
dc.contributor.authorLie, AKW-
dc.contributor.authorLeung, AYH-
dc.contributor.authorLiang, RHS-
dc.date.accessioned2010-09-25T19:31:42Z-
dc.date.available2010-09-25T19:31:42Z-
dc.date.issued2000-
dc.identifier.citationThe 2000 Tandem BMT Meetings, 26 March-1 April 2000. In Biology of Blood and Marrow Transplantation, 2000, v. 6 n. 2, p. 124, abstract no. 27-
dc.identifier.issn1083-8791-
dc.identifier.urihttp://hdl.handle.net/10722/100994-
dc.descriptionCombined annual meetings of CIBMTR and the American Society of Blood and Marrow Transplantation (ASBMT)-
dc.descriptionpp. 116-161 of this journal issue entitled: Abstracts from the Annual Tandem Meetings of the American Society for Blood and Marrow Transplantation and the International Bone Marrow Transplant Registry/Autologous Blood and Marrow Transplant Registry ... 2000-
dc.description.abstractThe present study investigated the effects of non-Total Body Irradiation (TBI) conditioning on the outcome of 8 patients (CML = 5 ; A M L = 3; Mean age 32.8 ± 3.3) undergoing Matched-Unrelated Bone Marrow Transplantation (MUD BMT) using busulfan (16 mg/kg) and cyclophosphamide (150 mg/kg). The outcome of 28 patients ( C M L = 16; AML = 7; Biphenotypic acute leukaemia = 2; ALL = 2 ; M D S = 1) using TBI (12Gy) containing regimen (Mean age 29.3 ± 1.7 ) were also analyzed. The number of days requiring TPN (due to oral mucositis) was significantly lower in the Bu-Cy group (18 ± 3.6 days) compared with the control (31.9 ± 4.1 days, p<0.05). There were no differences in neutrophil (ANC > 0.5 x 10 9/L) and platelet (>25 x 109/ L without transfusion) engraftments. The Bu-Cy group had less venoocclusive disease (VOD) (2/8 vs 11/28 in control) but more haemorrhagic cystitis (HC) (3/8 vs 5/28 in control) though the differences were not s i g n i ficant (p>0.05). Patients in the Bu-Cy group also had a signific a n t l y lower occurrence (1/8) of severe GVHD (Overall grade ³2) than the control group (18/28) (p<0.05). Transplant-related mortality (TRM) within 100 days after BMT was 0 in the Bu-Cy group but was 7 (out of 28) in the control (GVHD related = 4; Regimen-related toxicity = 2 ; Graft failure = 1). The difference, however, did not reach statistical sign i ficance (p>0.05). There was no difference in the occurrence of early graft failure in both groups of patients (1/8 in the Bu-Cy group vs 3/28 in the control). In conclusion, we have shown that the use of Bu-Cy during conditioning in MUD BMT had no adverse effect on neutrophil and platelet engraftments and did not increase the occurrence of graft failure. TBI based conditioning was associated with increased severity of oral mucositis and increased risk of VOD and severe GVHD and a higher transplant-related mortality.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bbmt-
dc.relation.ispartofBiology of Blood and Marrow Transplantation-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleA comparison of non-TBI and TBI conditioning regimens in bone marrow recipients undergoing match-unrelated transplantation in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailLie, AKW: akwlie@hku.hk-
dc.identifier.emailLeung, AYH: ayhleung@hku.hk-
dc.identifier.emailLiang, RHS: rliang@hku.hk-
dc.identifier.authorityLeung, AYH=rp00265-
dc.identifier.authorityLiang, RHS=rp00345-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1083-8791(00)70075-9-
dc.identifier.hkuros60341-
dc.identifier.volume6-
dc.identifier.issue2-
dc.identifier.spage124, abstract no. 27-
dc.identifier.epage124, abstract no. 27-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats