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Our research focuses on stem cell and cancer stem cell biology covering from basic to clinical research. Our study, for the first time, demonstrates the presence of the putative hematopoietic stem/progenitor cell (HSPC) population in human adult liver, which opens a new path for understanding of extra-marrow hematopoiesis, liver regeneration, tolerance in organ transplantation, and de novo cancer recurrence in transplantation patients. Moreover,we are the first to raise the concept that human stem cells possess DNA damage checkpoint, which is essential for genomic stability of SC.We then extend the research to potential roles of cell cycle regulators in controllingof pluripotency and differentiation in normal stem cells and liver cancer stem cells, aiming to provide a molecular basis for translating research.