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Professor Tse, Hung Fat 謝鴻發

Title:
Clinical Professor
Deputy Director of Institute of Cardiovascular Science and Medicine
William M W Mong Professor in Cardiology
Professor, Chair of Cardiovascular Medicine

Department:
Department of Medicine

Faculty:
Li Ka Shing Faculty of Medicine

Principal Investigator
StatusProject CodeProject TitleAmountFunding Year
 
PiH/328/21Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model3026192021
 
R7036-21Therapeutic application of induced pluripotent stem cells derived mesenchymal stromal cells for treatment of heart failure140571432021
 
PiH/204/21Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model3869252021
 
InP/056/21Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model1694902021
 
PiH/110/20Manufacture of Hepatocytes from Induced Pluripotent Stem Cells4690992020
 
PiH/226/20Manufacture of Hepatocytes from Induced Pluripotent Stem Cells4020532020
 
GHP/130/18SZManufacture of Hepatocytes from Induced Pluripotent Stem Cells10760232019
 
InP/020/20Manufacture of Hepatocytes from Induced Pluripotent Stem Cells3780002020
 
InP/021/20Manufacture of Hepatocytes from Induced Pluripotent Stem Cells3542222019
 
InP/181/19Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model4854222019
 
InP/288/19Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model4279632019
 
17120517Klf4 interacts with PCG-1/ERR to regulate mitochondrial biogenesis and dynamics in rescuing complex I dysfunction-provoked mesenchymal stem cell ageing9282002017
 
GHP/046/17GDGeneration of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model9674402017
 
N_HKU 722/05Hypoxia-mediated differentiation of murine and human embryonic stem cells into cardiomyocytes: mechanistic roles of calcium and ion channels7960002005
 
HKU 780110MAutologous Induced Pluripotent Stem Cells Derived Cardiomyocytes for Cardiac Repair in Porcine Ischemic Cardiomyopathy16000002010
 
HKU 779512MTherapeutic Effects and Mechanism of Sympathorenal Axis Modulation by Catheter-based Renal Denervation in Porcine Model of Ischemic Heart Failure13482502012
 
HKU 781111MAttenuation of Left Ventricular Remodeling and Improvement of Myocardial Function with Spinal Cord Stimulation in Post-myocardial Infarction Heart Failure10100002011
 
ITS/303/12Viral-Vector Integration-Free Human Induced Pluripotent Stem Cells Platform Derived from Urine Samples for Disease Diagnosis and Drug Screening9930312012
 
HKU 7357/02MNeovascularization of ischemic myocardium by autologous bone marrow cells transplantation8160002002
 
HKU 7459/04MFunctional role of pacemaker current, I(f) in sinoatrial node probed by somatic gene transfer of bioengineered HCN channels in swine10512802004
 
HKU 7594/05MEmbryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling6989572005
 
N_HKU 730/12Targeted gene correction and disease modeling using Wilson's disease induced pluripotent stem cells10276192012
 
HKU 7633/06MGenetic enrichment of cardiac derivatives from human embryonic stem cells and their bioengineering for cell-based heart therapies11545002006
 
203217Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with ""End-Staged"" coronary artery disease14000002003
 
HKU 776908MTransplantation of Bioengineered Human Embryonic Stem Cell-derived Cardiomyocytes with Mature Electrical Phenotype in Post-infarction Heart Failure Improves Cardiac Function Without Proarrhythmia11295162008
 
208207Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with ""end-stage"" ischaemic heart failure19650002008
 
HKU 8/CRF/09Pluripotent Human Stem Cell Platform for Tissue Regeneration and Drug Screening for Cardiovascular Diseases67000002009
 
T12-705/11Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform337050002011
 
HKU 780013MEffects of Catheter-based Splanchnic Denervation on Blood Pressure Control and Left Ventricular Remodeling in Porcine Model of Hypertensive Cardiomyopathy10392392013
 
17121014Lower Thoracic Spinal Cord Stimulation for Treatment of Heart Failure with Preserved Ejection Fraction: Insight from a Porcine Model of Hypertensive Cardiomyopathy8658902014
 
ITS/087/14Development of Wireless Powered Miniature Pacing Devices for Cardiac Rhythm Management13999932014
 
10111531Mendelian randomization to causally infer the impact of life-long vitamin D deficiency on Cardiovascular disease and death: implications for community-based cardiovascular prevention9990002012
 
N/ADiscovery of New Approaches for Treating Hyperlipidemia Using an Induced Pluripotent Stem Cell (iPSC)-Based Platform10000002015
 
AR160106Sudden Unexpected Death (SUD) in Hong Kong12480002016
Co-Investigator
StatusProject CodeProject TitleAmountFunding Year
 
17126923Glucagon-like Peptide-1 Receptor Agonist for Reduction of Peri-operative Myocardial Injury in Non-cardiac Surgeries: A Randomized Controlled Trial10726962023
 
17108523A Randomized Controlled Trial on Effects of Ivabradine for Strict Rate Control in Persistent Atrial Fibrillation: Ameliorating Myocardial Dysfunction and Inflammation12938442023
 
20211921Importance of attributes and willingness to pay for lipid-lowering agents in patients with hypercholesterolemia in Hong Kong: a discrete choice experiment11220402022
 
HKU 469/96MElectromechanical remodelling of chronically fibrillating atrium after transvenous atrial defibrillation6920001996
 
HKU 778212MExploring the role of bone marrow-derived mesenchymal stromal/stem cells in nephropathies9800002012
 
HKU 7338/01MVolume-sensitive chloride current and cell volume regulation in human atrial myocytes7340002001
 
HKU 777910MDriven Maturation of Embryonic Stem Cell-Derived Cardiomyocytes via Cardiac Hypertrophic Signals12000002010
 
ITS/150/12Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application9482322012
 
06070951A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer7716002007
 
HKU 7582/06MEndothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products12765502006
 
01121616Mutational spectrum for dilated cardiomyopathy in Hong Kong9172702013
 
InP/027/13Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application2200102012
 
2151207Provision of free non-vitamin K antagonist oral anticoagulants for poor and sick patients with atrial fibrillation who have high ischemic stroke risk6940802015
 
HKU 768411MEffects of chronic periodontitis on endothelial progenitor cells: Molecular mechanisms and clinical implications7900002011
 
HKU 776912MHuman Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform for Friedreich Ataxia9500002012
 
HKU 777713MCardiac fibroblasts derived Human induced pluripotent cells for cardiac regeneration7361282013
 
ITS/109/02Development of multi-feature physiological signal classifier and detector for medical diagnoses38595002002
 
03143726Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies12000002015
 
HKU 2/07CVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention55000002007
 
17111320Therapeutic potential of Synthetic Chemically Modified mRNA to ameliorate cardiac dysfunction associated with Danon disease caused by monogenic LAMP2 mutation.9962852020
 
05161936Patient-specific isogenic iPSCs-derived cardiomyocytes as a clinically relevant platform for the identification of therapeutic targets for Rett syndrome9540242017
 
03143996Reversibility of liver stiffness after tricuspid annulopasty: A case-control study9642162015
 
HKU 775812MPharmacological induction of leukotriene B4 12-hydroxydehydrogenase (LTB4DH) for the resolution of neutrophil-induced myocardial injury11646052012
 
HKU 763312MDoes an elevated lipocalin-2 concentration in plasma lead to endothelial dysfunction and hypertension?11588942012
 
17120715Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis5547002015
 
17127219Establishment of porcine expanded potential stem cells and their use for human disease modelling11160192019
 
HKU 777508MAtrial Mechanical Dyssynchrony and Function in Sinus Node Disease Patients With And Without Atrial Fibrillation: Impacts of Different Modes of Atrial and Ventricular Pacing5989172008
 
HKU 7555/06MA prospective randomized trial of endovascular stent graft repair versus best medical treatment for patients with acute Type B aortic dissection13359062006
 
HKU 785013MRelationship between matrix G1a protein and osteogenic endothelial progenitor cells with vascular and valvular calcification in patients with rheumatoid arthritis: Potential therapeutic role of vitamin K6495242013
 
201007176100Functional Characterization of human iPSC- derived mesenchymal stem cells with cardiomyocyte potential508112010
 
17106917Clinical Insight into Xi-chromosome Reactivation and its Therapeutic Potential in X-linked cardiomyopathies and related disorders.7848002017
 
200907176179Generation of mesenchymal stem cells from human induced pluripotent stem cells (iPS) for the treatment of limb ishcemia600002009
 
04152186Prospective evaluation of the impact of Drug-Coated Balloon in the management of true coronary bifurcation disease11215202016
 
HKU8/CRF/10Self-Assembled Synthetic Ion Channels: Design, Characterization and Biomedical Applications36000002010
 
17123122Dystrophinopathy patient-derived iPSC disease model for novel epigenetic mechanisms evaluation and advancing small molecules therapies development. 11156012022
 
HKU 7325/00MRole of nitric oxide synthase and cyclooxygenase2 in angiogenesis after acute myocardial infarction - therapeutic implication by L-arginine8004002000
 
HKU 770108MCalcium Signals and Cell Proliferation in Human Cardiac Fibroblasts13969042008
 
HKU 785611MMechanism and Reversibility of Myocardial Fibrosis in Patients with Diabetic Cardiomyopathy: Role of Aliskiren.9500002011
 
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HKU 7347/03MIonic channels of mesenchymal stem cells from bone marrow and cell proliferation6240002003
 
HKU 777707MPrevalence and clinical implications of exercise-induced left ventricular dyssynchrony detected by echocardiography in patients with coronary artery disease7008962007
 
02133066Comparative Evaluation of Combined Coronary Computed Tomography Angiography and Myocardial Perfusion Versus Cardiac Magnetic Resonance Imaging Myocardial Perfusion for Diagnosis of Coronary Artery Disease9402962014
 
HKU 7490/06MGenomic and proteomic basis of endothelial dysfunction in regenerated endothelium9545002006
 
HKU 780613MHERC2 as a regulator of endothelial senescence by modulating SIRT1/LKB1 signaling axis9526362013
 
HKU 779407MThalassaemia major: a new MRI method for detection and monitoring of heart and liver iron deposition11040182007
 
GHP/027/05Development of a Suspension Antibody Array-based Multiplex Immunoassay for Early Diagnosis and Therapeutic Monitoring of Diabetes and Cardiovascular Diseases28990452005
 
HKU 7307/00MStudy of the mechanisms of vascular homeostasis in obstructive sleep apnoea6960002000
 
InP/079/13Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application1696422013
 
HKU 774708MLong-term Efficacy and Safety of a Gene-based Bio-artificial Pacemaker tested in a large animal Sick Sinus Syndrome Model15525642008
 
HKU 775613MNovel Therapeutic Approach for X-linked related Danon Disease Insight from Patient-specific Pluripotent Stem Cells Platform.9526362013
 
HKU 782610MMRI Investigation of Left Ventricular Structure and Function12000002010
 
HKU 777208MCauses of Dysfunction in Regenerated Endothelium9966212008
 
17105319Myocardial Tissue Engineering with Cells Derived From Human-Induced Pluripotent Stem Cells and a Native Decellularized Placenta Scaffold10815152019
 
200809159006Comparing differentiation propensity among mescenchymal stem cells derived from sources of human embryonic stem cell lines, term placenta and bone morrow1200002008
 
06171686Precision medicine towards familial cardiac laminopathy14996642018
 
C7018-14EMicro-PET for pre-clinical molecular imaging research in Hong Kong80014862014
 
HKU 762607MDo biomarkers of inflammation and obesity predict the development of hypertension in Hong Kong Chinese?9000392007
 
14151121Effect of puerarin supplementation on cardiovascular disease risk factors: a randomized, double-blind, placebo-controlled, 2-way crossover trial11999062017
 
2151205Provision of Free B-type Natriuretic Peptide Testing for Poor and Sick Patients with Fluid Overload to Improve Heart Failure Management2707502015
 
CFS-HKU5Risk of cardiovascular diseases and related disorders in Hong Kong Chinese: Building on the strength of the Hong Kong Cardiovascular Risk Factors Prevalence Study (1995-2018)74995322018
 
2151206Free computed tomography coronary angiography for poor and sick patients to evaluate for coronary artery disease4800002015
 
N/AMRI compatible Cycle Ergometer to create Exercise Induced Stress Response for Cardiac Disease Research9912002018
 
21778046Arachidonic acid metabolite (15-keto-PGF2α) regulates macrophage M1/M2 polarization against myocardial ischemia reperfusion injury via covalent conjugation with glycolytic enzyme PKM28164002017
 
N_HKU 716/09Generation of corneal epithelial stem cells from human induced pluripotent stem cells (iPSC) and application for corneal epithelial tissue engineering7440002009