Investigating the role of Epac in the differentiation of mouse and human embryonic stem cells into insulin-producing cells
Dr Lam, Amy Ka Man (Principal investigator)
Epac, Embryonic stem cells, Insulin-producing cells
HKU Project Code
Research Centre of Heart, Brain, Hormone and Healthy Aging - General Award
To determine the role of Epac on the expression of beta-cell specific markers in the differentiation of mouse and human embryonic stem cells into pancreatic beta-cells; to determine the effect of Epac knockout in the differentiation of mouse embryonic stem cells to pancreatic beta cells; to determine the survival and in vivo function of Epac transduced or Epac analogue treated hESC-derived insulin-producing cells.