Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Grant Data
Project Title
Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Principal Investigator
Professor Lan, Hui Yao
(Principal Investigator (PI))
Duration
28
Start Date
2008-05-01
Completion Date
2010-04-30
Amount
430000
Conference Title
Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Keywords
Gene therapy, Hypertension, nephropathy, Smad7, TGF-beta
Discipline
Nephrology/UrologyGene Regulation
HKU Project Code
N/A
Grant Type
Baxter Health Care Ltd. - General Award
Funding Year
2006
Status
Completed
Objectives
To explore the role of TGF-beta/Smad signaling mechanisms in hypertensive nephropathy and develop a novel gene therapy for the hypertensive nephropathy using ultrsound-microbubble-mediated inducible Smad7 strategy.