The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance


Grant Data
Project Title
The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance
Principal Investigator
Dr Lin, Chen-Lung   (Principal investigator)
Co-Investigator(s)
Dr Xu Xiaoning   (Co-Investigator)
Professor Austyn Jonathan M.   (Co-Investigator)
Duration
36
Start Date
2002-11-01
Completion Date
2005-10-31
Amount
1224000
Conference Title
Presentation Title
Keywords
HIV immunopathology, dendritic cell function, T cell responses
Discipline
Allergy/Immunology
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7242/02M
Grant Type
General Research Fund (GRF)
Funding Year
2002/2003
Status
Completed
Objectives
The project attempts to characterize the role of DC-DIGN in the regulation of dendritic cell function, and to evaluate the inhibitory effect of DC-SIGN-modulated DC on T cell responses to primary and recall antigens in vitro and in vivo. This study will provide critical insights into the molecular mechanisms whereby DC-SIGN contributes to immunosuppression or peripheral tolerance, which may allow us to design more effective strategies for antiviral therapies and the induction of transplantation tolerance.