The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance
Grant Data
Project Title
The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance
Principal Investigator
Professor Lin, Chen-Lung
(Principal Investigator (PI))
Co-Investigator(s)
Professor Austyn Jonathan M.
(Co-Investigator)
Dr Xu Xiaoning
(Co-Investigator)
Duration
36
Start Date
2002-11-01
Amount
1224000
Conference Title
The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance
Presentation Title
Keywords
dendritic cell function, HIV immunopathology, T cell responses
Discipline
Allergy/Immunology
HKU Project Code
HKU 7242/02M
Grant Type
General Research Fund (GRF)
Funding Year
2002
Status
Completed
Objectives
The project attempts to characterize the role of DC-DIGN in the regulation of dendritic cell function, and to evaluate the inhibitory effect of DC-SIGN-modulated DC on T cell responses to primary and recall antigens in vitro and in vivo. This study will provide critical insights into the molecular mechanisms whereby DC-SIGN contributes to immunosuppression or peripheral tolerance, which may allow us to design more effective strategies for antiviral therapies and the induction of transplantation tolerance.