Mechanisms of enhanced monocyte binding to vascular endothelium in hyperhomocysteinemia


Grant Data
Project Title
Mechanisms of enhanced monocyte binding to vascular endothelium in hyperhomocysteinemia
Principal Investigator
Dr O, Karmin   (Principal investigator)
Duration
36
Start Date
2002-09-01
Completion Date
2005-08-31
Amount
1216575
Conference Title
Presentation Title
Discipline
Cardiovascular Research
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7249/02M
Grant Type
General Research Fund (GRF)
Funding Year
2002/2003
Status
Completed
Objectives
The project aims to investigate the effect of elevated blood homocysteine (Hcy) levels on monocyte binding to aortic endothelium in dietary-induced hyperhomocysteinemic rats as well as the underlying mechanisms. Specifically, efforts will be made to investigate the mechanisms of MCP-1 expression in endothelium and CCR2 expression in peripheral blood moncytes.