Discovery and clinical evaluation of novel immunogenic peptides for immunotherapy of nasopharyngeal carcinoma


Grant Data
Project Title
Discovery and clinical evaluation of novel immunogenic peptides for immunotherapy of nasopharyngeal carcinoma
Principal Investigator
Dr Lin, Chen-Lung   (Project coordinator)
Co-Investigator(s)
Dr Yu Wing Yiu   (Deputy project coordinator)
Duration
36
Start Date
2002-06-01
Completion Date
2005-05-31
Amount
3133000
Conference Title
Presentation Title
Keywords
cancer
Discipline
Genomic Biology
HKU Project Code
ITS/211/01
Grant Type
Innovation and Technology Support Programme
Funding Year
2001/2002
Status
On-going
Objectives
To prepare MAP/polyepitope of the LMP1/LMP2 native peptides; to identify highly immunogenic MAPs of the LMP1/LMP2 native peptides by in vitro immunoassays and in reactivating the CTL lines from asymptomatic carriers or NPC patients; to prepare LMP1/LMP2 templated peptide libraries; to identify highly immunogenic peptides from the synthetic peptide libraries by in vitro immunoassays and in reactivating the CTL lines from asymptomatic carriers or NPC patients; to prepare MAP/polyepitope of the synthetic peptide(s) for amplification of immunogenecity; to identify novel peptide candidates for clinical studies; to formulate studies of immunogenic peptides and MAPs; to pulse the dendritic cells from NPC patents with the lead peptides/MAP, followed by intradonal injection into the patients; to evaluate tumor growth in patients with local recurrence or metastasis.