Cardioprotective effects of female sex hormone as a result of negative modulation of [beta]-adrenoceptor - mechanisms of action


Grant Data
Project Title
Cardioprotective effects of female sex hormone as a result of negative modulation of [beta]-adrenoceptor - mechanisms of action
Principal Investigator
Professor Wong, Tak Ming   (Principal investigator)
Duration
36
Start Date
2001-10-01
Completion Date
2004-09-30
Amount
699600
Conference Title
Presentation Title
Keywords
sex hormone
Discipline
Others - Medicine, Dentistry and Health
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7312/01M
Grant Type
General Research Fund (GRF)
Funding Year
2001/2002
Status
Completed
Objectives
To test the hypothhesis that female sex hormone may produce cardioprotection by negatively modulating the [beta]-AR, the predominant receptor in the heart responding to the sympathetic nervous system; to determine whether the signaling pathway that mediates the rappid actions of estrogen, involves the messengers, known to mediate the action of membrane receptors.