Probing the mechanisms of magnesium tanshinoate B: inhibition on stress-activated protein kinase cascade in the ischaemic/reperfused heart
Dr Siow, Yaw Loong (Principal investigator)
Dr O Karmin (Co-Investigator)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To examine the role of magnesium tanshinoate B (MTB), a bioactive compound isolated from Danshen, in cardiovascular disease. Specifically, the project will investigate the effect of MTB on stress-activated protein kinase signalling pathway (shown to mediate apoptosis), on the lipoprotein-SAP kinase interaction, and on gene expression pattern after ischaemia/reperfusion.