Probing the mechanisms of magnesium tanshinoate B: inhibition on stress-activated protein kinase cascade in the ischaemic/reperfused heart


Grant Data
Project Title
Probing the mechanisms of magnesium tanshinoate B: inhibition on stress-activated protein kinase cascade in the ischaemic/reperfused heart
Principal Investigator
Dr Siow, Yaw Loong   (Principal investigator)
Co-Investigator(s)
Dr O Karmin   (Co-Investigator)
Duration
36
Start Date
2000-12-01
Completion Date
2003-11-30
Amount
763200
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7356/00M
Grant Type
General Research Fund (GRF)
Funding Year
2000/2001
Status
Completed
Objectives
To examine the role of magnesium tanshinoate B (MTB), a bioactive compound isolated from Danshen, in cardiovascular disease. Specifically, the project will investigate the effect of MTB on stress-activated protein kinase signalling pathway (shown to mediate apoptosis), on the lipoprotein-SAP kinase interaction, and on gene expression pattern after ischaemia/reperfusion.