Regulation of monocyte chemoattractant protein-1 (MCP-1) expression in atherosclerosis


Grant Data
Project Title
Regulation of monocyte chemoattractant protein-1 (MCP-1) expression in atherosclerosis
Principal Investigator
Dr O, Karmin   (Principal investigator)
Duration
36
Start Date
2000-09-01
Completion Date
2003-08-31
Amount
763200
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7346/00M
Grant Type
General Research Fund (GRF)
Funding Year
2000/2001
Status
Completed
Objectives
Homocysteinemia (elevated blood levels of homocysteine) is an important risk factor for cardiovascular disorders due to atherosclerosis. The present study aims to investigate the molecular mechanisms of homocysteine stimulation on the MCP-1 expression in endothelial cells, smooth muscle cells, monocytes/macrophages.