A study on the development of heparin and other similar polysaccharides from Angelica Sinensis Diels as new antiulcer agents for gastric ulcer
Professor Cho, Chi Hin (Principal investigator)
Dr Ko Ka Shun Joshua (Co-Investigator)
Professor Mei Qibing (Co-Investigator)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To study the ulcer healing effects of heparin in a gastric ulcer model and determine which fraction of polysaccharides from the unfractionated heparin is responsible for such effects; to investigate whether the ulcer healing effect of heparin is acting t through the anti-inflammatory action together with the stimulation of proliferation and angiogenesis at the ulcer site; to delineate which mediators and growth factors are involved in these actions; to isolate similar types of polysaccharides from Dang gui as compared with heparin and investigate their mechanisms of antiulcer action; to isolate a group of compounds with specific molecular sizes of polysaccharides with significant antiulcer property but with less anticoagulant activity.