A study on the development of heparin and other similar polysaccharides from Angelica Sinensis Diels as new antiulcer agents for gastric ulcer


Grant Data
Project Title
A study on the development of heparin and other similar polysaccharides from Angelica Sinensis Diels as new antiulcer agents for gastric ulcer
Principal Investigator
Professor Cho, Chi Hin   (Principal investigator)
Co-Investigator(s)
Dr Ko Joshua Ka Shun   (Co-Investigator)
Professor Mei Qibing   (Co-Investigator)
Duration
30
Start Date
1998-12-01
Completion Date
2001-05-31
Amount
835000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7257/98M
Grant Type
General Research Fund (GRF)
Funding Year
1998/1999
Status
Completed
Objectives
To study the ulcer healing effects of heparin in a gastric ulcer model and determine which fraction of polysaccharides from the unfractionated heparin is responsible for such effects; to investigate whether the ulcer healing effect of heparin is acting t through the anti-inflammatory action together with the stimulation of proliferation and angiogenesis at the ulcer site; to delineate which mediators and growth factors are involved in these actions; to isolate similar types of polysaccharides from Dang gui as compared with heparin and investigate their mechanisms of antiulcer action; to isolate a group of compounds with specific molecular sizes of polysaccharides with significant antiulcer property but with less anticoagulant activity.