A study on the development of heparin and other similar polysaccharides from Angelica Sinensis Diels as new antiulcer agents for gastric ulcer
Grant Data
Project Title
A study on the development of heparin and other similar polysaccharides from Angelica Sinensis Diels as new antiulcer agents for gastric ulcer
Principal Investigator
Professor Cho, Chi Hin
(Principal Investigator (PI))
Co-Investigator(s)
Dr Ko Ka Shun Joshua
(Co-Investigator)
Professor Mei Qibing
(Co-Investigator)
Duration
30
Start Date
1998-12-01
Amount
835000
Conference Title
A study on the development of heparin and other similar polysaccharides from Angelica Sinensis Diels as new antiulcer agents for gastric ulcer
Presentation Title
Keywords
null
Discipline
N/A
HKU Project Code
HKU 7257/98M
Grant Type
General Research Fund (GRF)
Funding Year
1998
Status
Completed
Objectives
To study the ulcer healing effects of heparin in a gastric ulcer model and determine which fraction of polysaccharides from the unfractionated heparin is responsible for such effects; to investigate whether the ulcer healing effect of heparin is acting t through the anti-inflammatory action together with the stimulation of proliferation and angiogenesis at the ulcer site; to delineate which mediators and growth factors are involved in these actions; to isolate similar types of polysaccharides from Dang gui as compared with heparin and investigate their mechanisms of antiulcer action; to isolate a group of compounds with specific molecular sizes of polysaccharides with significant antiulcer property but with less anticoagulant activity.