Isolation and identification of the ulcerogenic component(s) in cigarette smoke: their mechanisms of action on ulcer formation and healing


Grant Data
Project Title
Isolation and identification of the ulcerogenic component(s) in cigarette smoke: their mechanisms of action on ulcer formation and healing
Principal Investigator
Professor Cho, Chi Hin   (Principal investigator)
Co-Investigator(s)
Professor Wang Jian-Ying   (Co-Investigator)
Dr Zhu M   (Co-Investigator)
Duration
24
Start Date
1997-11-01
Completion Date
1999-10-31
Amount
500000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 7277/97M
Grant Type
General Research Fund (GRF)
Funding Year
1997/1998
Status
Completed
Objectives
It is known that there is a close relationship between cigarette smoking and peptic ulceration. Epidemiology studies showed that cigarette smokers were found to have more ulcers and they were usually healed slower but relapsed faster. However, which ulcerogenic substances in cigarette smoke are responsible for sucy actions and also the mechanisms by which cigarette smoke affects ulcer formation and healing, are still undefined. Therefore the purposes of this study are to isolate and identify this substance(s) and study how this substance(s) affects ulcer formation and healing.