Spatial patterns of growth factor gene expression as a factor contributing to the characteristic topographical distribution of B lymphocyte lineage cells in bone marrow
Grant Data
Project Title
Spatial patterns of growth factor gene expression as a factor contributing to the characteristic topographical distribution of B lymphocyte lineage cells in bone marrow
Principal Investigator
Dr Opstelten, Davina
(Principal Investigator)
Duration
42
Start Date
1995-01-01
Amount
646000
Conference Title
Spatial patterns of growth factor gene expression as a factor contributing to the characteristic topographical distribution of B lymphocyte lineage cells in bone marrow
Presentation Title
Keywords
Spatial patt, topographical distribution
Discipline
Biochemistry
HKU Project Code
HKU 374/94M
Grant Type
General Research Fund (GRF)
Funding Year
1994
Status
Completed
Objectives
To correlate, by visualizing specific mRNA, the topograpical distribution patterns in BM of cells expressing genes coding for (in vitro defined) growth factors with that of B lineage cells; to correlate, using immunohistology, the topographical distribution patterns in BM of the protein products of the genes mentioned; to use the data obtained to assess the likelyhood of a particular grwoth factor to play a regulatory role (positive or negative) in B lymphocytopoiesis in vivo.