Spatial patterns of growth factor gene expression as a factor contributing to the characteristic topographical distribution of B lymphocyte lineage cells in bone marrow
Dr Opstelten, Davina (Principal investigator)
Spatial patt, topographical distribution
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To correlate, by visualizing specific mRNA, the topograpical distribution patterns in BM of cells expressing genes coding for (in vitro defined) growth factors with that of B lineage cells; to correlate, using immunohistology, the topographical distribution patterns in BM of the protein products of the genes mentioned; to use the data obtained to assess the likelyhood of a particular grwoth factor to play a regulatory role (positive or negative) in B lymphocytopoiesis in vivo.