Spatial patterns of growth factor gene expression as a factor contributing to the characteristic topographical distribution of B lymphocyte lineage cells in bone marrow


Grant Data
Project Title
Spatial patterns of growth factor gene expression as a factor contributing to the characteristic topographical distribution of B lymphocyte lineage cells in bone marrow
Principal Investigator
Dr Opstelten, Davina   (Principal investigator)
Duration
42
Start Date
1995-01-01
Completion Date
1998-06-30
Amount
646000
Conference Title
Presentation Title
Keywords
Spatial patt, topographical distribution
Discipline
Biochemistry
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 374/94M
Grant Type
General Research Fund (GRF)
Funding Year
1994/1995
Status
Completed
Objectives
To correlate, by visualizing specific mRNA, the topograpical distribution patterns in BM of cells expressing genes coding for (in vitro defined) growth factors with that of B lineage cells; to correlate, using immunohistology, the topographical distribution patterns in BM of the protein products of the genes mentioned; to use the data obtained to assess the likelyhood of a particular grwoth factor to play a regulatory role (positive or negative) in B lymphocytopoiesis in vivo.