Helicobacter pylori lectins - identification, characterization, and purification for clinical applications


Grant Data
Project Title
Helicobacter pylori lectins - identification, characterization, and purification for clinical applications
Principal Investigator
Professor Lam, Shiu Kum   (Principal investigator)
Co-Investigator(s)
Dr Ching Chi Kong   (Co-Investigator)
Dr Zhu   (Co-Investigator)
Duration
24
Start Date
1996-11-01
Completion Date
1998-10-31
Amount
337000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 465/96M
Grant Type
General Research Fund (GRF)
Funding Year
1996/1997
Status
Completed
Objectives
To improve our understandings of the H.pylori surface lectins and to develop a typing system for H.pylori by using these lectins as markers; to develop an animal model to test if H.pyori lectins could be exploited as vaccine antigens to prevent gastric H.pylori colonization; to test if specific oligosaccharides can displace H.pylori from gastric epithelial surface so that naturally occuring compounds bearing these oligosaccharide epitopes can be used as therapeutic agents to eliminate gastric H.pylori colonization.