Regulaton of cytosolic Ca+2 concentration in endothelial cells


Grant Data
Project Title
Regulaton of cytosolic Ca+2 concentration in endothelial cells
Principal Investigator
Professor Kwan, David Chiu Yin   (Principal investigator)
Duration
36
Start Date
1994-10-01
Completion Date
1997-09-30
Amount
503000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 367/94M
Grant Type
General Research Fund (GRF)
Funding Year
1994/1995
Status
Completed
Objectives
To test the hypothesis that in endothelial cells the intracellular Ca+2 store, presumably the endoplasmic reticulum (ER), effectively communicate with the plasmalemmal Ca+2 channels; to test the hpothesis that Ca+2 entry in endothelial cells utilizes non-selective cation channels; to test the hypothesis that [beta]-adrenoceptor agonists interact with endothelial cells by lowering the intracellular Ca+2; to test the above hypotheses in vascular muscle tissues by simultaneous measurement of fura-2 fluorescence and tension development.