Regulaton of cytosolic Ca+2 concentration in endothelial cells
Professor Kwan, David Chiu Yin (Principal investigator)
RGC General Research Fund (GRF)
HKU Project Code
General Research Fund (GRF)
To test the hypothesis that in endothelial cells the intracellular Ca+2 store, presumably the endoplasmic reticulum (ER), effectively communicate with the plasmalemmal Ca+2 channels; to test the hpothesis that Ca+2 entry in endothelial cells utilizes non-selective cation channels; to test the hypothesis that [beta]-adrenoceptor agonists interact with endothelial cells by lowering the intracellular Ca+2; to test the above hypotheses in vascular muscle tissues by simultaneous measurement of fura-2 fluorescence and tension development.