The use of cytochrome-P450-dependent 5 hydroxylation inhibitor in combination with an antiarrhythmic for the treatment of paroxysmal atrial fibrillation


Grant Data
Project Title
The use of cytochrome-P450-dependent 5 hydroxylation inhibitor in combination with an antiarrhythmic for the treatment of paroxysmal atrial fibrillation
Principal Investigator
Professor Lau, Chu Pak   (Principal investigator)
Co-Investigator(s)
Professor Chow   (Co-Investigator)
Duration
48
Start Date
1993-10-01
Completion Date
1997-09-30
Amount
566000
Conference Title
Presentation Title
Sponsor
RGC General Research Fund (GRF)
HKU Project Code
HKU 321/93M
Grant Type
General Research Fund (GRF)
Funding Year
1993/1994
Status
Completed
Objectives
To assess the incidence polymorphic oxidative metabolism of propafenone in Chinese patients (Phase 1); to evaulate the relative efficacy of a cytochrome-P450-dependent 5-hydroxylation (CDH) inhibitor (using low dose quinidine) in combination with standard dose propafenone versus high dose propafenone in the management of patients with PAF refractory to standard doses of propafenone (Phase 2 and 3); to assess the efficacy of regular dose quinidine in combination with standard dose propafenone in an open label treatment in patients resistant to Phase 2 and 3 (Phase 4).