The use of cytochrome-P450-dependent 5 hydroxylation inhibitor in combination with an antiarrhythmic for the treatment of paroxysmal atrial fibrillation
Grant Data
Project Title
The use of cytochrome-P450-dependent 5 hydroxylation inhibitor in combination with an antiarrhythmic for the treatment of paroxysmal atrial fibrillation
Principal Investigator
Professor Lau, Chu Pak
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chow
(Co-Investigator)
Duration
48
Start Date
1993-10-01
Amount
566000
Conference Title
The use of cytochrome-P450-dependent 5 hydroxylation inhibitor in combination with an antiarrhythmic for the treatment of paroxysmal atrial fibrillation
Presentation Title
Keywords
null
Discipline
N/A
HKU Project Code
HKU 321/93M
Grant Type
General Research Fund (GRF)
Funding Year
1993
Status
Completed
Objectives
To assess the incidence polymorphic oxidative metabolism of propafenone in Chinese patients (Phase 1); to evaulate the relative efficacy of a cytochrome-P450-dependent 5-hydroxylation (CDH) inhibitor (using low dose quinidine) in combination with standard dose propafenone versus high dose propafenone in the management of patients with PAF refractory to standard doses of propafenone (Phase 2 and 3); to assess the efficacy of regular dose quinidine in combination with standard dose propafenone in an open label treatment in patients resistant to Phase 2 and 3 (Phase 4).